Abstract not available
Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.
Highlights Fluoride induced histological changes in the liver tissue. Fluoride induced significant damage to hepatocyte in mice. Fluoride caused notable mitochondrial morphological structure change. Drp1/Mff signaling pathway was involved in fluoride-induced mitochondria division. Fluoride induced apoptosis in hepatocyte. Fluoride, a toxic substance, is widely distributed in the environment and causes
Effect of fluoride on brain of albino-rabbit - An experimental study.
Background: Fluoride is present in environment in various forms and ingested by man from solid foods, drinking water and inhaled from the air. Out of these, fluoride is present in large quantities in dissolved state in many sources of drinking water producing toxicity in man. Fluoride can cross the blood-brain
Apoptotic and Oxidative Mechanisms in Liver and Kidney Tissues of Sheep with Fluorosis.
This study was planned to determine the molecular basis and causes of damage to the kidney and the liver, which are the most affected tissues in sheep exposed to chronic fluoride. For this purpose, liver and kidney tissues were obtained from sheep with signs of fluorosis in the age range
Fluoride-induced cell cycle arrest, apoptosis, and DNA damage in TM3 mouse leydig cells
This study was designed to evaluate the effect of fluoride (F) on the cell cycle, apoptosis, and DNA damage in TM3 mouse Leydig cells in vitro by the methods of flow cytometry (FCM) and single cell gel electrophoresis (SCGE). TM3 mouse Leydig cells were exposed to 0, 200, 400, 600,
In Vivo Comparison of the Phenotypic Aspects and Molecular Mechanisms of Two Nephrotoxic Agents, Sodium Fluoride and Uranyl Nitrate.
Because of their nephrotoxicity and presence in the environment, uranium (U) and fluoride (F) represent risks to the global population. There is a general lack of knowledge regarding the mechanisms of U and F nephrotoxicity and the underlying molecular pathways. The present study aims to compare the threshold of the
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