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Effects on DNA damage and apoptosis and p53 protein expression induced by fluoride in human embryo hepatocytes.
OBJECTIVE: To study the effects of DNA damage and apoptosis and p53 expression, and to explore the relationship between apoptosis and p53 expression in human embryo hepatocytes induced by fluoride. METHODS: The rate of DNA damage, apoptosis and the level of p53 expression were investigated after the cells were incubated with
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells.
Highlights Fluoride induced apoptosis in SH-SY5Y cells. Fluoride induced apoptosis via activating mitochondrial p53 apoptotic pathway. Fluoride inhibited SIRT1 deacetylase activity to activate p53. SIRT1 is a promising target to protect against fluoride-induced neurotoxicity. There has been a great concern about the neurotoxicity of fluoride since it can pass through the
[Excessive fluoride inducing calcium overload and apoptosis of ameloblasts].
OBJECTIVE: To study the effect of excessive fluoride on calcium overload and apoptosis in cultured rat ameloblasts in vitro. METHODS: Logarithmic-phase ameloblasts (HAT-7) were treated with 0, 0.4, 0.8, 1.6, 3.2, and 6.4 mmol · L(-1) sodium fluoride (NaF) solution. Cell activities were detected by using a Cell Counting Kit
Effect of sodium fluoride on the expression of bcl-2 family and osteopontin in rat renal tubular cells.
Our earlier studies showed that the apoptosis of renal tubules can be induced by sodium fluoride (NaF). The present study was designed to estimated the effects of B-cell lymphoma/leukemia 2 (Bcl-2), Bcl-2-associated protein X (Bax), and osteopontin (OPN) on the apoptosis of renal tubular cells induced by NaF at different
The effects and underlying mechanism of excessive iodide on excessive fluoride-induced thyroid cytotoxicity
In many regions, excessive fluoride and excessive iodide coexist in groundwater, which may lead to biphasic hazards to human thyroid. To explore fluoride-induced thyroid cytotoxicity and the mechanism underlying the effects of excessive iodide on fluoride-induced cytotoxicity, a thyroid cell line (Nthy-ori 3-1) was exposed to excessive fluoride and/or excessive
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