Fluoride Action Network


White mice maintained on water containing 100 ppm NaF showed changes in the enzyme level in serum, liver, kidney, heart and skeletal muscles. Enzymes studies were alkaline phosphatase (ALP), acid phosphatase (AcP), glutamate-oxalacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), lactic dehydrogenase (LDH), isocitric dehydrogenase (ICDH) and cholinesterase (CE). AcP was markedly decreased in liver and slightly in serum. ALP was markedly decreased in skeletal muscle, slightly decreased in heart muscle and liver but increased in kidney and serum. No significant changes were observed in GOT and LDH. GPT was slightly decreased in liver, and ICDH was decreased in liver, kidney, heart and skeletal muscles. (Environmental pollution by fluoride is discussed.)