Abstract

The pilot study was conducted on 10 adult albino rats of either sex 150 – 200gm each. Two equal groups of control and experimental was made. The control group received food and water ad libitum whereas experimental group received 30 ppm of NaF for 8 weeks. The macroscopic features like body weight, general activity was markedly reduced in experimental group pertaining to high fluoride levels in the brain. Light microscopy of cerebrum in experimental group revealed decreased density of neurons, high mitotic figures. The density of neurons was reduced to 93.4 cells / cumm from 149.6 cells / cumm in control.

Excerpt:

RESULTS

Behavioural

The rats became sluggish/less reactive progressively with the administration of sodium fluoride as compared to control group. It reflects effect of sodium fluoride on its motor activities. Microscopic Mitotic figures are seen in the experimental group. The observations at 40x revealed reduced neuronal density in Cerebrum as shown in figure – 1. Quantitative estimate of neuronal density per unit area as compared to Control Group (CG) and the Experimental Group (EG) showed significant changes in neuronal density (Table 1). Sodium fluoride decreases the neuronal density.

Microscopic

Mitotic figures are seen in the experimental group. The observations at 40x revealed reduced neuronal density in Cerebrum as shown in figure – 1. Quantitative estimate of neuronal density per unit area as compared to Control Group (CG) and the Experimental Group (EG) showed significant changes in neuronal density (Table 1). Sodium fluoride decreases the neuronal density.

 

Print PDF

• Related Studies :

  • Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats

    Spontaneous motor activity and motor coordination were tested in adult female rats after treating with sodium fluoride at 20 or 40 mg/kg dose level daily for 60 days, using an activity chamber and a rota-rod apparatus, respectively. Total protein concentrations were determined in skeletal muscle, liver and serum of similarly

  • Pathological changes in the tissues of rats (albino) and monkeys (macaca radiata) in fluorine toxicosis

    1. Stomach, duodenum, small intestine, kidney, liver, spleen, skin, heart, aorta, lungs, brain, pancreas, adrenals, thyroid and parathyroid of rats and monkeys suffering from chronic fluorosis have been histologically examined. 2. Fluorine has not been found to have any effect on the heart muscle, aorta, skin and parathyroids, whereas it has

  • Sodium fluoride affects zebrafish behaviour and alters mRNA expressions of biomarker genes in the brain: Role of Nrf2/Keap1

    Highlights Sodium fluoride (NaF) treatment changed the behaviour of zebrafish. Expression of antioxidant genes was upregulated. Expression of Nrf2 and its related genes were also altered. Results indicated that Nrf2 plays a significant role in NaF induced neurotoxicity. Sodium fluoride (NaF), used as pesticides and for industrial purposes are deposited

  • Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats.

    Highlights The influence of rutin on fluoride – induced neurotoxicity in rat was studied. Rutin reversed the fluoride – induced neurobehavioral deficits in rats. Rutin reversed the fluoride – induced inhibition of acetylcholinesterase activity in rat cerebrum and striatum. Rutin enhanced antioxidant status and inhibited neuro-inflammation and apoptosis in fluoride

  • Neurobehavioral and neurochemical effects in rats offspring co-exposed to arsenic and fluoride during development.

    Highlights Arsenic/Fluoride co-exposure during development causes neurobehavioral alterations in offspring. iAs/F causes delayed development of sensorimotor reflexes and produces less nociceptive response. iAs/F co-exposure increase locomotor activity. Antioxidant enzymes and neurotransmitter level are altered in the striatum area. Arsenic (iAs) and fluoride (F) are ubiquitous in the environment. All over

• Related FAN Content :

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • Fluoride & IQ: 76 Studies

    Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.