Abstract
Mortality trends from 1950 to 1970 were studied for 473 cities in the United States with populations of 25,000 or more in 1950, according to fluoridation status of their water supplies. Findings showed no relationship between fluoridation and observed changes in general mortality over the 20-year period. Also, no relationship was found between fluoridation and heart or cancer death rate trends.
Author Address: Div. Heart Vasc. Dis., Epidemiol. Branch, Natl. Heart Lung Blood Inst., Room 2C-08, Fed. Build., Bethesda, Md. 20014, USA.
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Acute sodium fluoride poisoning.
Severe acute sodium fluoride poisoning occurred in a man following the ingestion of 120 gm of sodium fluoride (NaF). Toxic reactions included tetany, multiple episodes of ventricular fibrillation, and esophageal stricture. The management of this case resulted in the patient's survival. To our knowledge, no similar case has been found
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Changes of the heart muscle due to chronic fluorosis. Part 1: Electrocardiogram and cardiac x-rays in inhabitants of a high fluoride zone
1) The author examined inhabitants of a high fluoride zone (Shionoe village, Kagawa Prefecture, and Odani villAge, Sanyo town, Okayama Prefecture). ln residents of these zones , greater myocardial damage was detected electrocardiographically and dilatation of the cardiac sillouette roentgenograpbically than in n0n-fluoride areas. 2) The myocardial damage appears to
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Fluoride and generation of pro-inflammatory factors in human macrophages
Fluorosis from excessive exposure to fluoride can result in inflammatory reactions involving macrophages and their differentiation, a process that is rapidly followed by generation of prostanoids—products of arachidonic acid metabolism, including the pro-inflammatory factors prostaglandin PGE2 and thromboxane TXA2, which are implicated in atherogenesis and rapidly increase during acute inflammation. This paper examines the effect
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Analysis of x-ray heart areas of 30 patients with endemic fluorosis
I. Targets and methods Based on diagnosis standards formulated at the 1981 Shijiazhuang National Prevention of Endemic Fluorosis Meeting, 30 patients were chosen, 15 men and 15 women with an average age of 45, average height of 1.63 meters, and average weight of 54 kilograms, and all with clinical diagnoses
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Interactive effect of arsenic and fluoride on cardio-respiratory disorders in male rats: possible role of reactive oxygen species.
Epidemiological evidence demonstrates positive correlation between environmental and occupational arsenic or fluoride exposure and risk to various cardio-respiratory disorders. Arsenic-exposure has been associated with atherosclerosis, hypertension, cerebrovascular diseases, ischemic heart disease, and peripheral vascular disorders, whereas Fluoride-exposure manifests cardiac irregularities and low blood pressure (BP). Present study aims to study
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Fluoride & Arteriosclerosis
Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the
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Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
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Fluoride, Blood Pressure and Hypertension
Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et
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Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
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Fluoride & Myocardial Damage
Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha
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