Abstract
Mortality trends from 1950 to 1970 were studied for 473 cities in the United States with populations of 25,000 or more in 1950, according to fluoridation status of their water supplies. Findings showed no relationship between fluoridation and observed changes in general mortality over the 20-year period. Also, no relationship was found between fluoridation and heart or cancer death rate trends.
Author Address: Div. Heart Vasc. Dis., Epidemiol. Branch, Natl. Heart Lung Blood Inst., Room 2C-08, Fed. Build., Bethesda, Md. 20014, USA.
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The effects of the inhalation of hydrogen fluoride. I. The response following exposure to high concentrations.
The effects of inhalation exposure to hydrogen-fluoride (7664-39-3) (HF) were examined in New-Zealand-white-rabbits and guinea-pigs. Animals were exposed to HF in enclosed chambers at concentrations ranging from 8 to 0.024 milligrams per liter (mg/l) for 5 minutes to 41 hours. Mortality rates were recorded, general physical conditions were monitored, and
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Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta.
Epidemiological and experimental studies have demonstrated the atherogenic effects of environmental toxicant arsenic and fluoride. Inflammatory mechanism plays an important role in the pathogenesis of atherosclerosis. The aim of the present study is to determine the effect of chronic exposure to arsenic and fluoride alone or combined on inflammatory response
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Sodium fluoride produces a K+ efflux by increasing intracellular Ca2+ through Na+-Ca2+ exchange.
Acute fluoride intoxication increases intracellular calcium (Cai), manifested by increased twitch tension in cardiac muscle, and by potassium efflux (mediated by Ca2+-dependent K+ channels) in fluoridated erythrocytes. Fluoride, like isoproterenol, stimulates adenylate cyclase, and could increase Cai via the effects of cAMP on Ca2+ channels. However, while the inotropic effects
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Chronic fluoride toxicity and myocardial damage: antioxidant offered protection in second generation rats
This experiment was designed to investigate the extent of peroxidative changes and histological alterations in the myocardium of rats exposed to high fluoride for two generations, in addition to ameliorative role of selenium and vitamin E on the above indices. Adult albino Wistar rats were given fluoride through drinking water
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Assessment of relationship on excess fluoride intake from drinking water and carotid atherosclerosis development in adults in fluoride endemic areas, China.
Cross-sectional analysis was conducted to access the relationships between developing carotid artery atherosclerosis through consuming high fluoride in drinking water and its possible mechanism, using the baseline data collected from 585 study subjects. In the cross sectional analysis, subjects were divided into four groups based on the concentrations of fluoride
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