Abstract
Exposure of rats to the combined effect of HF and SO2 decreased body weight, O2 consumption and myoglobin levels in muscles and increased the erythrocyte level in blood. Low and high concentrations of HF and SO2 decreased cytochrome oxidase activity in almost all organs and had a toxic effect on succinate dehydrogenase activity in lung, liver and brain tissue. The combined effect of the 2 gases on most indices was of the summation type.
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A possible mechanism for combined arsenic and fluoride induced cellular and DNA damage in mice
Arsenic and fluoride are major contaminants of drinking water. Mechanisms of toxicity following individual exposure to arsenic or fluoride are well known. However, it is not explicit how combined exposure to arsenic and fluoride leads to cellular and/or DNA damage. The present study was planned to assess (i) oxidative stress
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Oxidative stress parameters in rats exposed to fluoride and caffeine
In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated. Also, the influence of caffeine on fluoride excretion with urine was studied. Thirty adult male Wistar rats
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A study of the intellectual ability of 8-14 year-old children in high fluoride, low iodine areas.
Wechsler Intelligence Test IQ scores of 160 children, 8–14 years old, from nine schools in an area of high fluoride and low iodine averaged 64.8 compared with 85.0 (p<0.01) for 169 children of the same ages from seven schools in an area with low iodine only. Among the first group
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[Influence of free radical inducer on the level of oxidative stress in brain of rats with fluorosis].
OBJECTIVE: To study changes in content of lipid peroxide and composition of fatty acids in the brain of rats affiliated with chronic fluorosis after treatment with free radical inducer (ferric ion). METHODS: Thirty-six Wistar rats were divided into three groups, fed with similar fodder and varied concentrations of fluoride in drinking
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Correlations between fluoride concentration and free radical parameters in soft tissues of rats.
In previous studies we investigated the impact of subchronic exposure of rats to sodium fluoride administered in their drinking water as it affected selected biochemical parameters in their soft tissues and organs. The activity of glutathione peroxidase and the concentrations of fluoride, reduced glutathione (GSH), substances reacting with thiobarbituric acid (TBARS), and carbonyl groups were determined in kidney,
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Fluoride & IQ: 76 Studies
• As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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