The prognosis for fluoride inhalation is poor, owing to the extreme toxicity of the substance and lack of satisfactory treatment. In the case of massive inhalation, the slow, progressive destruction of the bronchial mucosa and lung tissue will be lethal. Irrespective of the dose, a transient restriction in renal function or acute renal failure will occur. The transient increase in transaminase seems to be caused by several factors. Our cases show that the evaluation of fluoride levels in biological material is difficult, as dietary intake, e.g., in drinking water, may complicate acute or chronic occupational exposure.
Relationship between fluoride deposition and metastatic calcification in soft tissues of rat and guinea pig
Two studies have been conducted to investigate whether there is a relationship between the disposition of fluoride in various soft tissues of rats and guinea pigs and the levels of calcium and phosphorous in the tissues. The results suggest that when rats receive a stock corn diet there is a
Changing patterns of renal osteodystrophy with chronic hemodialysis
The concept that osteomalacia becomes progressively worse on chronic dialysis was reinforced by the findings in the repeat bone biopsies in that 6 of the 8 patients showed a significant increase in their osteoid index. . . . Thus, the progression of osteomalacia appears to be the main reason for
Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.
Highlights Fluoride induced renal function disorder. Fluoride induced kidney structure damage. Fluoride inhibited renal cells proliferation. Fluoride interfere the expression of mitochondrial respiratory chain complexes. Fluoride elevates mitochondrial fusion. A fluoride exposure mouse model is established to evaluate the relationship between mitochondrial respiratory chain complexes and renal dysfunction. Morphological changes in
Effects of fluoride and aluminum exposure to dams prior to and during gestation on mineral compositions of bone and selected soft tissues of female mice dams and pups.
Sixty-four CD-1 female mice were assigned to onez of four water treatment groups: Control (distilled, deionized water) (C); Fluoride (50 ppm F as NaF) (F); Aluminum (100 ppm Al as AlCl3) (Al); and Al & F (50 ppm F & 100 ppm Al) (AlF). One-half of the animals in each
Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity
This study describes alterations in the nervous system resulting from chronic administration of the fluoroaluminum complex (AlF3) or equivalent levels of fluoride (F) in the form of sodium-fluoride (NaF). Twenty seven adult male Long-Evans rats were administered one of three treatments for 52 weeks: the control group was administered double
Related Studies :