The prognosis for fluoride inhalation is poor, owing to the extreme toxicity of the substance and lack of satisfactory treatment. In the case of massive inhalation, the slow, progressive destruction of the bronchial mucosa and lung tissue will be lethal. Irrespective of the dose, a transient restriction in renal function or acute renal failure will occur. The transient increase in transaminase seems to be caused by several factors. Our cases show that the evaluation of fluoride levels in biological material is difficult, as dietary intake, e.g., in drinking water, may complicate acute or chronic occupational exposure.
Effect of chronic fluoride exposure in uremic rats
This study was conducted to test the hypothesis that the margin of safe fluoride exposure is narrowed in rats that are physiologically compromised by renal dysfunction. The study objective was to determine whether increases in fluoride retention and tissue fluoride levels in rats with surgically induced renal insufficiency result in
The role of calcium in ameliorating the oxidative stress of fluoride in rats
The present study was carried out to investigate the effects of fluoride toxicity on some biochemical, hormonal, and histological parameters of female rats and the protective role of calcium against such effects. Adult female albino rats were divided into five groups; control group received distilled water for 60 days, calcium
High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiency
Renal insufficiency is known to increase plasma fluoride levels, which may increase the risk of fluorosis and osteomalacia. The purpose of this study was to determine the effects of fluoride on skeletal fragility and mineralization in renal-deficient animals. We evaluated the skeleton of rats with surgically induced renal deficiency (4/5
[Fluoride osteosis of hydro-telluric origin in a female patient with renal insufficiency. Apropos of a case with histomorphometric analysis].
We report a case of fluorosis due to high water and soil contents in a 23-year-old Algerian woman. The condition, which is infrequent at this age, was promoted by chronic renal failure due to a congenital renal malformation. Roentgenograms showing osteosis with increased bone density were suggestive of fluorosis rather
The effect of fluoride on the structure, function, and proteome of a renal epithelial cell monolayer
High concentrations of fluoride in the body may cause toxic effects. Here, we investigated the effects of fluoride on the structure, function, and proteome of a cortical collecting duct epithelium in vitro. Kidney tubule cells (M-1) were chosen because the concentration of fluoride in the kidney is 4-5-fold higher than
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