Abstract
X-ray examinations of 98 potroom workers at an aluminum refinery plant in China have been carried out to study skeletal disorders that might be related to f-exposure. The examinations included the pelvis, lumbar vertebrae, radius, ulna, tibia, and fibula. Changes in skeletal system, such as bone density and trabeculae structure, the appearance of osteophytes and exostosis, and the calcification of interosseous membranes and ligaments were assessed by two orthopedic surgeons with the double blind test. NO cases of typical skeletal fluorosis were found among the study group, but the appearance of lumbar vertebral osteophyte in the 45-54 year group, exposed to fluoride for more than 20 years, was significantly more frequent than that in the respective control groups No significant differences in other aspects of osteosclerosis between the F-exposed and the control groups were observed.
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Fluoride exposure altered metabolomic profile in rat serum
Highlights 58 NEG and 73 POS metabolites were altered in F-treated 3 weeks rat serum. 126 NEG and 70 POS metabolites were altered in F-treated 11 weeks rat serum. Four significantly different metabolites, nicotinamide, adenosine, 1-Oleoyl-sn-glycero-3-phosphocholine, and 1-Stearoyl-sn-glycerol 3-phosphocholine were shared by two models. Urea, N2-Acetyl-l-ornithine, and betaine were
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Effect of dietary fluorine on growth, blood and bone characteristics of growing-finishing pigs
Three hundred eighty-four growing-finishing pigs were used in two experiments to determine the effect of dietary fluorine (F) on growth, blood and bone physical characteristics. Fourteen dietary treatments were formulated by supplementing F (as NaF) to a milo-soybean meal basal diet (7 ppm F) to provide levels of 7, 132,
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The impact of fluoride in drinking water on oral health and skeletal system of school children
Modern life styles even among people in rural areas have created an increased demand for dental cosmetology. Dental fluorosis due to its cosmetic effect gains more public health importance today. In the scenario of increasing awareness of environmental health hazards, among people, the research into the biology of fluorosis conducted
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Some results of the effect of fluoride on bone tissue in osteoporosis
Three cases are reported in which fluoride was administered to individuals with osteoporosis. Bone biopsies taken after 7 to 24 months of therapy show that the effect of fluoride on bone tissue appears to be stimulation of new bone formation. If calcium and vitamin D are not administered with the
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Skeletal fluorosis from instant tea
INTRODUCTION: Skeletal fluorosis (SF) can result from prolonged consumption of well water with >4 ppm fluoride ion (F(-); i.e., >4 mg/liter). Black and green teas can contain significant amounts of F(-). In 2005, SF caused by drinking 1-2 gallons of double-strength instant tea daily throughout adult life was reported in
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
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"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
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