The biological effects of fluoride were investigated on rats fed pure spring water (natural F- concentration = 0.2 ppm) or spring water enriched with NaF to result 0.8, 1.1 or 2.2 ppm F- during 180 days. The main effects of fluoride have been:
1. Electrocardiographic recordings showed a significant reduction of the electrical systole (QTc).
2. Body weight gain was unaffected by the treatment.
3. Bivalent cations (Ca2+, Mg2+ and Zn2+) were importantly reduced in adrenals, ventricular myocardium, and bone.
4. Na+ concentration was strikingly increased in aorta, lung, and joint of treated animals.
5. In testis, we observed Ca2+ and Na+ retention.
6. Zinc ions were depleted in most tissues, except kidney and submandibular salivary gland.
Our results revealed that chronic administration of fluoridated water does influence systemic biochemical homeostasis in rats, without evoking any overt sign of fluorosis. Moreover, the definition of a “safe” concentration of F- in public w [abstract cut short]
Toxicology and Carcinogenesis Studies of Sodium Fluoride in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
CASRN: 7681-49-4 Chemical Formula: NaF Molecular Weight: 41.99 Report Date: December 1990 Sodium fluoride is a white, crystalline, water-soluble powder used in municipal water fluoridation systems, in various dental products, and in a variety of industrial applications. Toxicology and carcinogenesis studies were conducted with F344/N rats and B6C3F1 mice of each sex by incorporating
ESPEN micronutrient guideline
Background Trace elements and vitamins, named together micronutrients (MNs), are essential for human metabolism. Recent research has shown the importance of MNs in common pathologies, with significant deficiencies impacting the outcome. Objective This guideline aims to provide information for daily clinical nutrition practice regarding assessment of MN status, monitoring, and prescription. It proposes
New data for the validation of the mean daily maximum permissible concentration of hydrogen fluoride in atmospheric air
1. Round-the-clock exposure to hydrogen fluoride concentrations of 0.10 and 0.03 mg/m3 causes inhibition in the central nervous system, decreases the activity of a number of enzymes, impairs the phosphorus-calcium metabolism, and causes the accumulation of fluorine in the body and damage to the internal organs and bone tissue. 2. A
Acute fluoride poisoning.
Fluoride poisoning is a potentially severe environmental hazard for children. A case of fluoride poisoning is presented which was manifested by severe hypocalcemia, ventricular arrhythmias, and respiratory failure. Treatment of this poisoning, including peritoneal dialysis, is discussed. The kinetics of fluoride distribution as measured in this patient suggest a rapid
Further observations on radiological changes of endemic food borne skeletal fluorosis
Among radiological changes in 396 cases of foodborne skeletal fluorosis, from 4 endemic areas in Guizhou, China, osteoporosis, osteomalacia and impaired bone growth were seen in addition to previously recorded findings of osteosclerosis, bone prominences, joint changes and calcification of peripheral arteries. The deformity of genu valgum, a manifestation of
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
Fluoride & Arteriosclerosis
Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the
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