Abstract
Case reports are presented of 8 patients with end stage renal disease who while undergoing dialysis received IV, excessive amounts of fluoride due to an unreported spill of hydrofluosilicic acid into the public water supply caused by cross connections in a treatment plant. Water used to mix dialysis solutions in this unit was treated only by a softening device; no reverse osmosis or deionization had occurred. The afebrile illness, predominantly characterized by hypotension, nausea, substernal pain, diarrhea, itching, and vomiting, developed after one to 2 hr of dialysis. One patient upon autopsy was found to have high fluoride levels in lung tissue (5.6 ppm), kidney (7.0 ppm), brain (0.9 ppm) and blood (4.9 ppm). When a chemical accident does occur, public health officials should be immediately informed so that dialysis units and End Stage Renal Disease Networks in particular can be promptly notified. Finally, it is recommended that water purification techniques such as reverse osmosis and deionization be used to ensure high quality dialysate.
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Evaluation of free radical-scavenging and anti-oxidant properties of black berry against fluoride toxicity in rats
Oxidative damage to cellular components such as lipids and cell membranes by free radicals and other reactive oxygen species is believed to be associated with the development of degenerative diseases. Fluoride intoxication is associated with oxidative stress and altered anti-oxidant defense mechanism. So the present study was extended to investigate
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Fluoride distribution in rats during and after continuous infusion of Na18F.
Rats were given Na18F as a radiotracer for F- at varying chemical dose rates by continuous i.v. infusion for 3 h. Blood fluoride was assessed 6-7 times over the infusion period, at the end of which the animals were sacrificed for determination of tissue fluoride distribution. At sublethal dosages, the
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary
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Fluorosis by the Ministry of Health & Family Welfare, National Health, India.
Introduction Fluorosis is a crippling disease resulted from deposition of fluorides in the hard and soft tissues of body. It is a public health problem caused by excess intake of fluoride through drinking water/food products/industrial pollutants over a long period. Ingestion of excess fluoride, most commonly in drinking-water affects the teeth
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Oxidative stress parameters in rats exposed to fluoride and caffeine
In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated. Also, the influence of caffeine on fluoride excretion with urine was studied. Thirty adult male Wistar rats
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride & IQ: 67 Studies
As of May 2020, a total of 75 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 67 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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