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Methods: Male rats received sodium fluoride in their drinking water (1 ppm – tap water; 50 ppm; 100 ppm) for 30 days. After this period, different groups of animals were tested in openfield habituation (two 5-min sessions 24 h apart) and in the twoway active avoidance (two sessions of 30 trials with 10-s of tone – conditioned stimulus – and 5-s of 0.3mA shock delivery – unconditioned stimulus – at final 5 s of CS). Food and water intake, body weight gain and dental fluorosis were also recorded…
Discussion: Thirty days of sodium fluoride administration to rats induced impairment in habituation and two-way active avoidance. Possible mechanisms of these impairments can be the reduction of some subunits of nicotinic receptors and altered hippocampal calcium current found after chronic NaF treatment (Long et al., 2002). In conclusion, the present study reinforces the clinical impression that sodium fluoride has a potential memory impairment effect, which deserves further studies.
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Research on the neurobehavioural function of workers occupationally exposed to fluoride.
Sixty-five operations workers (all males) in an electrolytic aluminum production facility were divided into two groups. The first group of 37 was employed for more than 5 years, and the second group of 28 for 5 years or less. These men had no history of liver, kidney, or immune-related disease. X-ray tests indicated that they were not suffering
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Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
Background: Neonatal exposure to anesthetics that block Nmethyl D-aspartate receptors and/or hyperactivate -aminobutyricacid type A receptor has been shown to cause neuronal degeneration in the developing brain, leading to functional deficits later in adulthood. The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior
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Effects of fluoride on psychomotor performance and memory of aluminum potroom workers
In this cross-sectional study, the psychomotor performance and memory skills of a fluoride-exposed group (FEG) of 64 male workers in an aluminum potroom were compared with those of 60 male workers in a nonfluoride-exposed group (NFEG). The FEG had a mean age of 37.59±4.82 yr and had been employed for
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Influence of fluoride exposure on reaction time and visuospatial organization in children
Note: This is a conference abstract from the 2000 Annual Conference of the ISEE (International Society for Environmental Epidemiology). No full study has been published. Fluoride exposure is an important public health problem in several Mexican states. In the city of San Luis Potosi, Mexico, above 90% of the children have
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Effects of high fluoride level on neonatal neurobehavioral development
The effects of excessive fluoride intake during pregnancy on neonatal neurobehavioral development and the neurodevelopment toxicity of fluoride were evaluated. Ninety-one normal neonates delivered at the department of obstetrics and gynecology in five hospitals of Zhaozhou County, Heilongjiang Province, China were randomly selected from December 2002 to January 2003. The
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Fluoride & IQ: 76 Studies
• As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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