Excerpt:

Methods: Male rats received sodium fluoride in their drinking water (1 ppm – tap water; 50 ppm; 100 ppm) for 30 days. After this period, different groups of animals were tested in openfield habituation (two 5-min sessions 24 h apart) and in the twoway active avoidance (two sessions of 30 trials with 10-s of tone – conditioned stimulus – and 5-s of 0.3mA shock delivery – unconditioned stimulus – at final 5 s of CS). Food and water intake, body weight gain and dental fluorosis were also recorded…

Discussion: Thirty days of sodium fluoride administration to rats induced impairment in habituation and two-way active avoidance. Possible mechanisms of these impairments can be the reduction of some subunits of nicotinic receptors and altered hippocampal calcium current found after chronic NaF treatment (Long et al., 2002). In conclusion, the present study reinforces the clinical impression that sodium fluoride has a potential memory impairment effect, which deserves further studies.

Print PDF

• Related Studies :

  • Effects of high fluoride on neonatal neurobehavioral development.

    The effects of excessive fluoride intake during pregnancy on neonatal neurobehavioral development and the neurodevelopment toxicity of fluoride were evaluated. Ninety-one normal neonates delivered at the department of obstetrics and gynecology in five hospitals of Zhaozhou County, Heilongjiang Province, China were randomly selected from December 2002 to January 2003. The subjects were divided into two groups (high

  • Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice

    Background: Neonatal exposure to anesthetics that block Nmethyl D-aspartate receptors and/or hyperactivate
    -aminobutyricacid type A  receptor has been shown to cause neuronal degeneration in the developing brain, leading to functional deficits later in adulthood. The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior

  • Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats.

    Highlights Influence of taurine was studied in rat model of fluoride neurotoxicity. Taurine reversed the fluoride-induced neurobehavioural deficits. Taurine decreased intracellular hydrogen peroxide and lipid peroxidation levels. Taurine reversed the fluoride-induced inhibition of acetylcholinesterase activity. Taurine may be a potential therapeutic agent in fluoride-mediated neurotoxicity. Epidemiological and experimental studies have

  • Fluoride exposure during development affects both cognition and emotion in mice

    Highlights The developmental fluoride exposure to mice affects their emotional behaviors. The developmental fluoride declines both spatial and non-spatial cognition of mice. The high fluoride reduces the exercise tolerance of mice. Previous studies have suggested that sodium fluoride (NaF) may have adverse effects on neurodevelopment. In the present study, we evaluated

  • Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean.

    Environmental (and occupational) exposure to neurotoxic substances is a worldwide problem that can affect children's neurodevelopment (ND). In Latin American and Caribbean (LAC) countries there are over 300 million children living under the threat of neurodevelopmental delays due to toxic environmental exposure. Large industrial centers, intense mining and agricultural activities,

• Related FAN Content :

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching