Abstract
The influence of fluoride in drinking water on stone formation was studied in animals and in “in vitro” crystallization experiments. In male Wistar rats fluoride inhibits ethylenglycol induced calcification of the kidneys and stone formation. The in vitro results performed in synthetic urine exhibited a dose-dependent delay of crystal growth.
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[Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology]
The authors' research focuses on polyuria, natriuresis, glucosuria, glycemia, and renal calcification in occupational lead poisoning and endemic fluorosis. Changes in electrolyte mobilization and in glucose metabolism and transport following the administration of lead compounds or fluoride were examined to elucidate these mechanisms. The results suggest fundamental approaches to the
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Kidney changes and kidney stones in endemic fluorosis.
Urinary tract calculi obtained from 25 patients residing in an endemic fluorotic area revealed a significantly higher fluoride content compared to calculi from 25 persons from a nonendemic area. However the difference in their calcium and phosphate content was not significant. Twenty-four hour urinary fluoride excretion was significantly higher in
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Medical aspects of excessive fluoride in a water supply
A 10-year study of 116 persons in Bartlett and 121 in Cameron, Tex., was conducted to determine if prolonged exposure to fluoride in the water supply of Bartlett had produced detectable physiological effects. Bartlett's water contained about 8 p.p.m. F until 1952, when an experimental defluoridation unit was installed, reducing the
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Determination of fluoride ions in urinary stones by ion chromatography.
A method of the ion chromatographic determination of fluoride ions in urinary stones has been developed. Sample preparation of solid mineral-organic samples includes dissolution in concentrated hydrochloric acid, dilution with deionized water, and the elimination of excess calcium and magnesium cations by adding a KU-2 sulfo cation exchanger in the
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Effect of fluoride, silicon, and magnesium on the mineralizing capacity of an inorganic medium and stone formers urine tested by a modified in vitro method.
An in vitro mineralizing system using bovine achilles tendon developed by Thomas and Tomita (3) was modified to enable quantitative evaluation of mineralization. Using this modified method, the potential effect of various ions on the rate of calcium uptake from inorganic mineralization medium was measured. Of the elements tested, only
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