Abstract
The influence of fluoride in drinking water on stone formation was studied in animals and in “in vitro” crystallization experiments. In male Wistar rats fluoride inhibits ethylenglycol induced calcification of the kidneys and stone formation. The in vitro results performed in synthetic urine exhibited a dose-dependent delay of crystal growth.
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Recovery from skeletal fluorosis (an enigmatic, American case)
A 52-year-old man presented with severe neck immobility and radiographic osteosclerosis. Elevated fluoride levels in serum, urine, and iliac crest bone revealed skeletal fluorosis. Nearly a decade of detailed follow-up documented considerable correction of the disorder after removal of the putative source of fluoride (toothpaste). INTRODUCTION: Skeletal fluorosis, a crippling bone
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Effect of fluoride, silicon, and magnesium on the mineralizing capacity of an inorganic medium and stone formers urine tested by a modified in vitro method.
An in vitro mineralizing system using bovine achilles tendon developed by Thomas and Tomita (3) was modified to enable quantitative evaluation of mineralization. Using this modified method, the potential effect of various ions on the rate of calcium uptake from inorganic mineralization medium was measured. Of the elements tested, only
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Kidney changes and kidney stones in endemic fluorosis.
Urinary tract calculi obtained from 25 patients residing in an endemic fluorotic area revealed a significantly higher fluoride content compared to calculi from 25 persons from a nonendemic area. However the difference in their calcium and phosphate content was not significant. Twenty-four hour urinary fluoride excretion was significantly higher in
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[Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology]
The authors' research focuses on polyuria, natriuresis, glucosuria, glycemia, and renal calcification in occupational lead poisoning and endemic fluorosis. Changes in electrolyte mobilization and in glucose metabolism and transport following the administration of lead compounds or fluoride were examined to elucidate these mechanisms. The results suggest fundamental approaches to the
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Sodium fluoride increases intracellular calcium in rat renal epithelial cell line NRK-52E
In our previous experiment using rats, fluoride was reported to cause renal calcification, whose mechanism was deduced to be due to an increase in parathyroid hormone (PTH) secretion. However fluoride-induced renal calcification that was independent of PTH has not been understood well in the nephron of fluoride-treated animals. Thus, we
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