A description of the fluoride overfeed in Hooper Bay, Alaska, that resulted in the first reported death due to fluoride toxicity caused by drinking water from a community water system.
Pharmacokinetic aspects of topical fluorides
Pharmacokinetic studies have revealed quantitative information about the bioavailability, rate of absorption, distribution, and clearance of fluoride following the use of fluoride-containing dentifrices, gels, varnishes, and solutions. It is concluded that following the use of topical fluoride products, variable amounts of fluoride are swallowed and absorbed into the systemic circulation--amounts which may be sufficient to produce acute
Fluoride overfeed at a well site near an elementary school in Michigan.
A fluoride overfeed occurred at a well site near an elementary school in Portage, Michigan. The incident resulted in a high concentration of fluoride (92 milligrams per liter) in drinking water at the school. Seven students who drank water from the school fountain reportedly suffered nausea and vomiting. Toxicological evaluations
Sudden cardiac death from acute fluoride intoxication: the role of potassium.
The mechanism of sudden cardiac death following acute fluoride intoxication has been thought to result from profound hypocalcemia produced by the precipitation of calcium fluoride salts. In studies of a canine model, the onset of lethal ventricular arrhythmias was temporally more associated with an elevation of serum potassium than with
An outbreak of fatal fluoride intoxication in a long-term hemodialysis unit
OBJECTIVE: To determine the cause of an outbreak of acute illness and death in a long-term hemodialysis unit. DESIGN: A retrospective cohort and case-control study of patients receiving hemodialysis and a laboratory study of a model deionization system to purify water for hemodialysis. SETTING: An outpatient hemodialysis unit of a university hospital. PATIENTS:
Acute fluoride poisoning in a New Mexico elementary school.
Thirty-four persons became ill with acute fluoride poisoning shortly after drinking water in an elementary school in Los Lunas, NM. The water supply of the school was supplemented with a concentrated sodium fluoride solution designed to raise fluoride levels in drinking water to 1 to 5 ppm. Two water samples
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