Abstract
Until our knowledge of the etiology of Alzheimer’s dementia, as well as related conditions involving mental impairments, is greatly extended, no line of investigation should be ignored. We believed that the possible contributions of aluminum exposure to neural impairments deserved further study. In coming to this opinion we were mindful of the work of Roberts on the neurotoxic effects of inhaled aluminum silicate(1) as well as the neuropathologic results reported by Perl and his associates indicating an association of aluminum with disease-affected neurons in Alzheimer’s patients (2,3). The possibility that certain metals including aluminum, either alone or in combination, play a role in dementia remains a viable hypothesis(4). While the possibility of transport of Al to the brain via the olfactory system, especially under conditions of a partially compromised immune system, remains a likely route of entry into the nervous system, it is not the only entry route for aluminum. Al and other elements with toxic potential enter the nervous system through many pathways, including our food and water.
Initially, we investigated the effects of low doses of aluminum given to rats through their drinking water. The entry of Al into the circulation and the brain depends on the particular species of Al available as well as the conditions in the stomach and the digestive tract. The bioavailability of Al may be enhanced by its complexing with fluorine (F) to form various monomeric fluoaluminum species. Of these, AIF3 was of special interest due to its lipid solubility and ability to pass…
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The Wall Street Journal | October 28, 1992
By Marilyn Chase, Staff Reporter
Rat Studies Link Brain Cell Damage With Aluminum and Fluoride in Water
ANAHEIM, Calif. – A team of New York scientists said rat studies offer preliminary evidence that aluminum, when administered in drinking water, may be linked with behavior changes and damaged brain cells.The study, presented at the meeting here of the Society for Neuroscience, is the latest of several studies hinting at some link between aluminum in the environment and Alzheimer’s disease. Several controversial studies during the last four years found that Alzheimer’s disease seemed more prevalent in areas that added aluminum sulfate (alum) to the drinking water to clarify it.
Robert Isaacson, professor of psychology at the State University of New York at Binghamton, said he dosed the drinking water of 40 rats with graduated levels of aluminum and fluoride for 45 to 50 weeks.
Rats fed the highest doses developed irregular mincing steps characteristic of senile animals, in contrast with the long and regular strides of animals in their prime. In addition, the rats lost their normal ability to distinguish the scent of banana, which is their favorite, from lemon. Performance of other tasks wasn’t impaired.
Post mortem examination of the rat brains disclosed “substantial cell loss in structures associated with dementia – the neo-cortex and hippocampus,” said Dr. Isaacson. In the next phase of his research, he will employ antibody probes to determine whether the rat brains are riddled with telltale tangles of cell debris that are seen in Alzheimer’s patients.
Aluminum finds its way into human drinking water from acid rain, as well as through the use of clarifying agents. In addition, many cities add fluoride to their water systems to prevent tooth decay. However, Dr. Isaacson and his collaborators declined to correlate the amount of aluminum fluoride in their study with amounts that might be present in municipal drinking water. The researchers said they didn’t wish to cause alarm, but rather wanted to investigate whether fluoride speeds up the absorption of aluminum, and to make a case for further study.
Other experts are skeptical about aluminum’s role in triggering Alzheimer’s disease. “There is no evidence that aluminum starts the process,” said Konrad Beyreuther of the University of Heidelberg. But he acknowledged that the metal may accelerate the formation of brain plaques found in the disease, once it has begun.
Asked whether the public should worry, Dr. Isaacson said: “I think we ought to find out if we should worry. Our study alone isn’t definitive. But the possibility is important enough that it shouldn’t be ignored.”
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Chemical & Engineering News
April 27, 1998.
Brain damage in rats from fluoridated water
An animal study links low levels of fluoride in water to brain damage [Brain Res. 784, 284 (1998)]. The research was a collaboration among a chemist and two psychologists (including lead author Julie A. Varner) at Binghamton University, Binghamton, N.Y., and an EPA neurotoxicologist. Twenty-seven rats were divided into three groups and for one year were given either distilled water, distilled water with 2.1 ppm NaF-the same concentration of fluoride normally used in fluoridated drinking water-or distilled water with 0.5 ppm AIF3. In both treated groups, the aluminum levels in the brain were elevated relative to controls. The researchers speculate that fluoride in water may complex with the aluminum in food and enable it to cross the blood-brain barrier. Both treated groups also suffered neural injury and showed increased deposits of ß-amyloid protein in the brain, similar to those seen in humans with Alzheimer’s disease. “While the small amount of AIF3…required for neurotoxic effects is surprising, perhaps even more surprising are the neurotoxic effects of NaF” at 2.1 ppm, the authors write.
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