Abstract
The study was done in 30 one-month-old Wistar FL rats divided into one control and two study groups of ten animals each. Hyperglycemia was induced with sodium fluoride in water at a concentration of 50 or 100 mg/L during four months. Control animals received distilled water. We observed significantly (p < 0.05) reduced activities of aspartate aminotransferase (by 22.8%) and malic dehydrogenase (by 10.9%) in the group exposed to 100 mg F(-)/L. No pathological changes were revealed in the pancreas of exposed animals.
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Fluoride-induced resistance to insulin in the rat.
The insulinic response of rats challenged with glucose at different times after an oral dose of 40 µmol NaF/100 g bw revealed the concentration of the molecular species reacting with anti-insulin antibody was significantly lower after 3 hr, and the glucose levels were somewhat higher than in controls. At the
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Mathematical model of glucose-insulin homeostasis in healthy rats.
According to the World Health Organization there are over 220 million people in the world with diabetes and 3.4 million people died in 2004 as a consequence of this pathology. Development of an artificial pancreas would allow to restore control of blood glucose by coupling an infusion pump to a
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Activity of pancreatic antioxidative enzymes and malondialdehyde concentrations in rats with hyperglycemia caused by fluoride intoxication.
The aim of this work was to examine the effect of fluoride ions on antioxidative enzyme activity in the pancreas of rats exposed during 4 months to NaF in drinking water. The study was carried out in 30 four-week-old male Wistar FL rats, that were randomly assigned to three equal
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Effect of fluoride on the secretion of insulin in the rat.
Sodium fluoride (CAS 7681-49-4) 5-20 micromol/L in the extracellular space inhibited insulin secretion by isolated Langerhans islets stimulated with glucose. Insulin secretion followed a negative exponential function. This phenomenon is rapidly reversible. Perfusion of pancreatic tissue (rat) in vivo with stimulatory levels of glucose revealed that 20 micromol/L fluoride in
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Some current aspects of environmental fluoride
This review presents a Total Environment evaluation of current inorganic fluoride intake by human populations. Inorganicfluoride is a persistant bioaccumulator, and the ever-increasing use (and release) of fluoride compounds in the environment should be of long-term concern in population sub-groups who are most susceptible, and therefore, most "at risk". One of these sub-groups consists of
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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Fluoride & Insulin
Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics
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Fluoride Sensitivity Among Diabetics
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions
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Fluoride & Impaired Glucose Tolerance
The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs
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NRC (2006): Fluoride's Effect on Glucose Metabolism
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific
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