Abstract

SUMMARY: The aim of this study was to determine how metabolic and functional changes in diabetes affect the fluoride intake, distribution, and concentration in bone tissue; and whether alterations in fluoride metabolism in diabetes may influence the severity of the disorder. Two groups of rats received 0 (C) or 10 ppm (F10) fluoride via drinking water for three weeks, ad libitum. Two other groups were treated with a dingle dose of streptozotocin to induce diabetes, and also received 0 (D) or 10 ppm fluroide (DF10). The quantity of fluoride consumed via water by the DF10 animals was calculated daily and an equal amount was added to the drinking water of another group of non-diabetic animals (FF).

In the diabetic group (DF10) the intake of fluoride gradually increased, hyperglycemia was more severe, and renal hypertrophy was expressed less than in the diabetic group (D) which consumed deionized water. The femoral fluoride concentration increased in proportion to fluoride intake. The high fluoride intake of FF animals resulted, when compared to DF10 ones, in a further increase in the bone tissue and in relatively less elevation in plasma fluoride concentrations. It is concluded that (1) fluoride supply via drinking water may enhance the severity of diabetes in rats, and (ii) due to diabetic metabolic and functional imbalance, the fluoride metabolism may also change.

• Related Studies :

  • Effects of fluoride on insulin signaling and bone metabolism in ovariectomized rats

    Fluoride is an essential trace element for the maintenance of bone health owing to its capacity to stimulate proliferation and osteoblastic activity that can lead to increased bone formation. However, excessive sodium fluoride (NaF) intake can impair carbohydrate metabolism thereby promoting hyperglycemia, insulin resistance, and changes in insulin signaling. Thus,

  • The pathogenesis of endemic fluorosis: Research progress in the last 5 years.

    Fluorine is one of the trace elements necessary for health. It has many physiological functions, and participates in normal metabolism. However, fluorine has paradoxical effects on the body. Many studies have shown that tissues and organs of humans and animals appear to suffer different degrees of damage after long-term direct

  • Estimation of occupational hazards of the employees of a phosphate fertilizers plant.

    Composite examinations of 116 persons, employees of Phosphate Fertilizers Plant in Gdansk, with an average length of service ca. 15 years, were carried out. It was found that the frequency of occurrence of the chronic non-specific diseases of the lungs was not higher than in other works where dust and

  • Changes in the concentration of fluoride in the serum and bones of female rats with streptozotocin induced diabetes.

    The aim of this study was to determine if streptozotocin-induced diabetes in rats as a model for Type-1 human diabetes causes changes in the levels of fluoride (F) and biogenic elements in the bones and serum in the initial stage of the disease. Twenty-two female Wistar rats were given streptozotocin

  • Effects of fluoride on metabolism and mechanical properties of rat bone

    Young rats were maintained, over a 2-week period, on laboratory chow and distilled water or water supplemented with 200 ppm fluoride. Metaphyseal and diaphyseal bone of the femurs and tibias of control and treated rats were analyzed. After fluoride treatment there was a decrease of lipid and citrate content and

• Related FAN Content :

  • Fluoride & Osteoarthritis

    While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.

  • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus

    This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In

  • "Pre-Skeletal" Fluorosis

    As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.

  • Fluoride Sensitivity Among Diabetics

     This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions

  • Fluoride & Impaired Glucose Tolerance

    The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs