Abstract
The synaptic mechanism of learning-memory injury induced by chronic fluorosis in brain was investigated. 192 Sprague-Dawley (SD) male rats, one-month-old, were randomly divided into four groups and given 15, 30, 60 mg / L NaF solution and tap water respectively for 18 months. Behavior of rats was evaluated by open field and Morris Water Maze test every 3 months. The hippocampal synaptic membrane fluidity was detected by electron spin resonance, the expression level of post synaptic density 95 (PSD -95) in hippocampal CA3 region was detected by immunohistochemistry. Results showed that in rats with chronic fluorosis compared with the controls, locomotor activity and exploratory behavior were significantly or very significantly suppressed, spatial learning and memory ability were significantly declined;. synaptic membrane fluidity and the protein level of PSD-95 of hippocampus were greatly decreased. The data indicated that the changes of synaptosome membrane fluidity and PSD-95 expression level in hippocampus might be the one synaptic mechanism of learning-memory injury induced by chronic fluorosis in brain.
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Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the a7 nicotinic receptor and oxidative stress.
Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects
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Fluoride exposure decreased learning ability and the expressions of the insulin receptor in male mouse hippocampus and olfactory bulb.
Fluoride is one of the common environmental pollutants. Internal exposure to fluoride is related to the lowered cognitive function and intelligence, particularly for children. Determination of protein content in brain tissue is a means to reflect the functional development of the central nervous system. Insulin and insulin receptor (IR) signaling
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Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels.
Previous studies suggest that sodium fluoride (NaF) can impair performance in some memory tasks, such as open-field habituation and two-way active avoidance. In the present study, we evaluated the effect of NaF intake (100 ppm in drinking water for 30 days) and its short-term (15 days) withdrawal on open-field habituation and brain monoamine
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Attenuating effect of Vitamin E on the deficit of learning and memory of rats with chronic fluorosis: the mechanism may involve muscarinic acetylcholine receptors.
The protective role of vitamin E (Vit E) against neurotoxicity induced by fluorosis was investigated by using Sprague-Dawley (SD) rats fed with 50 ppm fluoride in drinking water for 10 months. Spatial learning and memory of rats were measured by the Morris water maze test; the expressions of M1 and
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Pathologic changes and effect on the learning and memory ability in rats exposed to fluoride and aluminum
Background: The aim of this study is to establish a single and combined intoxication model of fluoride and aluminum so as to observe the impact of these chemicals on the learning and memory ability and the pathologic changes in brain of rats. Methods: Forty male Wistar rats were randomly assigned
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Fluoride Affects Learning & Memory in Animals
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
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Fluoride's Direct Effects on Brain: Animal Studies
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Fluoride's Effect on Fetal Brain
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