Abstract
With the expansion of certain types of industrialization into agricultural areas, fluorosis in livestock has become an important toxicologic problem in some places in the United States and many other countries. Fluorine has beneficial effects when ingested in small amounts, but toxic and adverse effects when ingested in excessive amounts. Many sources may contribute to the total fluorine intake of animals. Various factors influence biologic responses of livestock to ingested fluorides. Fluorosis can be correctly diagnosed and evaluated by qualified individuals. Some methods and procedures are helpful in alleviating fluorine toxicosis. Several programs may be used for settlements and solutions of fluorosis problems. Standards and a comprehensive guide for use in diagnosing and evaluating fluorosis in livestock has been compiled.
Excerpt:
The onset of chronic fluorosis is insidious and may be confused with chronic debilitating diseases such as osteoarthritis . . .
-
-
Sodium fluoride modulates caprine osteoblast proliferation and differentiation
The cellular and molecular pathways of fluoride toxicity in osteoblasts are not very well understood. Therefore, the objective of the present study was to evaluate the effects of sodium fluoride (NaF) on caprine osteoblasts cultured in vitro. Caprine osteoblasts at 2.0 x 10(-4) cells/ml were incubated in vitro with NaF
-
Reversible skeletal disease and high fluoride serum levels in hematologic patients receiving voriconazole.
We here investigate the occurrence of fluoride intake-associated alterations in patients with hematologic disease on triazol antifungal medication. Clinical, laboratory, and radiology data of overall 43 patients with hematologic malignancies taking voriconazole (n = 20), posaconazole (n = 8), and itraconazole (n = 4), and a hematologic patient control group
-
Toxic effect of fluoride on biochemical parameters and collagen metabolism in osseous and non-osseous tissues of rats
The present study was carried out to assess the effects of fluoride exposure on collagen metabolism by evaluating the level of hydroxyproline in both osseous and non-osseous tissues along with serum biochemical parameters in rats. Eight week old female rats were divided into two equal groups of six rats each.
-
The effects of sodium fluoride on osteoporotic rats
Dr. Richard Daley, Dr. Lewis D. Anderson, and Dr. Richard S. Riggins discussed the effects of high fluoride diets on bone tissue. Severe restrictions of calcium intake in growing rats produces a histological picture resembling osteoporosis. In this study a control series of rats, fed adequate amounts of calcium, was
-
Sketetal changes in endemic fluorosis
Summary 1. The skeletal changes in endemic fluorosis are described from an area of the Punjab where the fluorine content of water and soil is very high. 2. A detailed description of a fluorotic skeleton is given, with its various anthropometric measurements. 3. The vertebral changes demonstrated the pathogenesis of the neurological complications
Related Studies :
-
-
-
Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
-
"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
-
Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
Related FAN Content :
-