Abstract
Axonal and dendrictic degenerations were observed in non-skeleton fluorosis as the neurological manifestations. Microtubules, composed of the assembled tubulin dimers, are the essential cytoskeleton of axon and dendron. However, the effect of fluoride (F) on microtubules status and tubulin dimer expression in central nerves system remains largely unknown. In this study, the ultrastructure of microtubules and expression of TubB1a and TubB2a were detected in hippocampus of mice orally administrated with 25, 50, or 100mgL(-1) NaF for 60d. Results showed that in F treatment groups, microtubules were broken into discrete fragments and bended, which were no longer stretched and went along the axon well. In addition, the expression of TubB1a and TubB2a on both gene and protein levels were significantly reduced in high F group. The visual results of immunocytochemistry also confirmed the decreased protein expressions of TubB1a and TubB2a. These findings suggested that microtubule lesions could be an important cause for neurodegeneration observed in fluorosis, and F may threaten the microtubule stability by affecting the expression of tubulin dimers.
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Aluminum and fluoride impacts cortex and hippocampus structure in rats: protective role of resveratrol.
Metals such as aluminum and Fluoride have been implicated in the etiology of several neurodegenerative disorders . Resveratrol, a natural polyphenol, exerting a wide range of biological and pharmacological activities including its antioxidative properties against neurodegenerative disorders through its ability to lessen oxidative stress. Rats were divided in to 4
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Effect of fluoride exposure on anxiety- and depression-like behavior in mouse.
Highlights Anxiety-like behavior was significantly altered in the mice exposed to NaF for 120 days. Depression-like behavior was significantly altered in the 120 days NaF treated mice. NaF significantly altered mRNA expression levels of anxiety- and depression-like related genes in the hippocampus. Fluoride led to an imbalance between excitation and
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Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice.
SUMMARY: Learning-memory behavior was tested in mice on a Y-maze after they drank water containing different concentrations of sodium fluoride. Impairment of the structure of the Gray I synaptic interface in the CA3 area of the hippocampus was analyzed quantitatively by electron microscopy and a computer imaging processor. The main
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Fluoride enhances the effect of aluminium chloride on interconnections between aggregates of hippocampal neurons
The role of fluoride in aluminium neurotoxicity was studied using an in vitro system of cultured hippocampal neurons from foetal rats. Sodium fluoride (50 microM) and aluminium chloride (12.5 microM) were administered alone or in a specific combination (50 + 12.5 microM) in a 14-day culture in a chemically defined
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Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.
Fluoride neurotoxicity is associated with mitochondrial disruption. Mitochondrial fission/fusion dynamics is crucial to maintain functional mitochondria, yet little is known about how fluoride perturbs this dynamics and whether such perturbation contributes to impaired neurodevelopment. Here in human neuroblastoma SH-SY5Y cells treated with sodium fluoride (NaF, 20, 40 and 60 mg/L), mitochondrial
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Fluoride Affects Learning & Memory in Animals
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Fluoride & IQ: 67 Studies
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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