Abstract

The objective of this study was to assess the protective effect of black berry juice (BBJ) on the neurological disorders and oxidative stress induced by co-exposure to ALCL₃ and NaF in male albino rats. Administration of either AlCl3 (200?mg/kg bw) or NaF (10?mg/kg bw) or both of them caused a significant increase in serum and brain TL, TC, TG as well as serum LDLC and VLDLC levels while serum HDLC level was decreased significantly. Additionally, brain neurotransmitter (DA and 5-HT) levels, AChE, Na-K ATPase activity and ATP values were decreased significantly but NE level was increased in rats administered Al or F alone or in combination. Moreover, a significant increase in brain MDA, NO, H2O2 and free radical enzyme (xanthine oxidase (XO)) and a significant decrease in the level of TAC, SOD and GSH were recorded in AlCl₃ or NaF intoxicated rats. In addition, the levels of serum Na, Ca, Cu and zinc (Zn) were significantly diminished, while the level of K was significantly increased. However ALCL₃ appears to enhance the neurotoxic hazards caused by NaF. On the other hand, the administration of BBJ (1.6?g/kg bw) showed a marked neuroprotective effect against the biochemical abnormalities that occurred and oxidative stress of the brain induced by co-exposure to AlCl₃ and NaF. So, it can be concluded that the consumption of BBJ might be useful for alleviating the neurological disorders and oxidative stress associated with concurrent exposure of ALCL₃ and NaF indicating its free radical scavenging and potent antioxidant activity.

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