Abstract
Sprague Dawley albino rats were treated with 30, 45, and 75 mg NaF/kg body weight/day respectively for 20 days and 35 days to study neurotoxic effect of fluoride. The control rats were injected with double distilled water 1cc/kg body weight/day. The animals were sacrificed and the cerebrum was analysed for neurodegenerative anomalies. The adenomatous foci were formed in the cerebral cortex containing degenerating glial cells. The glial cells became vacuolated and showed hyperchromatization of nuclei in brain of rats treated with 30 mg NaF/kg body weight/day. The chain formation of the disintegrated glial cells, senile plaque and large globose shaped neurofibillary tangle inside the perikaryon in cerebral cortex were observed in rats treated with 45 mg NaF/kg body weight/day. An elongated highly chromatolytic region with large number of vacuolated cells was visible. In some neurons, neuroplasm become hyperchromatic, fragmentation and apoptosis of nuclei was prominent. Pleomorphic, irregular glial cells showed necrosis, the cerebral cortex exhibited diffused haemorrhages in rats of 75 mg NaF dose group. The results of present study revealed a fairly consistent pattern of adverse effects by fluoride on cerebral neuropathology, which may be a cause of neurological sequelae and abnormal neuro-behavioural patterns in fluorosis.
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Effects of Calcium on Drinking Fluorosis-induced Hippocampal Synaptic Plasticity Impairment in the Offspring of Rats.
Objective: This study investigated the effects of calcium on fluorosis-induced impairment in learning and memory of offspring rats. Methods: Seventy-five newly weaned female Sprague-Dawley (SD) rats were randomly divided into five groups as follows: Control group (Control) drank tap water, and ate the normal diet (calcium content of 0.79%); fluoride group (F)
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Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats
Spontaneous motor activity, rota-rod performance (motor co-ordination), body weight gain, food intake, activities of total cholinesterase (blood) and acetylcholinesterase (brain), and dental structure were determined in adult female rats treated with a very high dose of sodium fluoride (500 ppm in drinking water) alone and in combination with calcium carbonate
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Fluoride-induced depletion of polyphosphoinositides in rat brain cortical slices: a rationale for the inhibitory effects on phospholipase C
Fluoride, which is used commonly as a pharmacological tool to activate phosphoinositide-phospholipase C coupled to the heterotrymeric Gq/11 proteins, inhibited the phosphorylation of phosphatidylinositol (PtdIns) to polyphosphoinositides (PtdIns4P and PtdIns4,5P2) in membranes from rat brain cortex. Fluoride enhanced basal production of 3H-inositol phosphates in membranes prepared from brain cortical slices
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DRAFT NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects
This DRAFT Monograph is distributed solely for the purpose of pre-dissemination peer review and does not represent and should not be construed to represent any NTP determination or policy. Background: Previous reviews of epidemiological studies, including a 2006 evaluation by the National Research Council (NRC), found support for an association between
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Neuroprotective effects of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in the brain of rats
Methyl-3-O-methyl gallate (M3OMG) is a rare natural product that showed promising in vitro antioxidant activities. In this study, the protective role of synthetic M3OMG against sodium fluoride (NaF)-induced oxidative stress in rat brain was evaluated. Animals were treated with either M3OMG (10 and 20 mg/kg i.p.), vitamin C (10 mg/kg
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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