Abstract

Objective: To explore the exact relationship between daily total intake of fluoride and children’s intelligence quotient (IQ).

Methods: Wamiao village (severely endemic fluorosis area, drinking water fluoirde was 0.57-4.50 mgL) and Hinhuai village (non-endemic fluorosis area, drinking water fluoride was 0.18-0.76 mgL^-1) in Shong County,  Jiangsu Province, were selected for this study. All 8-13 year old students in two village primary schools were recruited as subjects in this study. Children’s IQ, drinking water fluoride in children’s household shallow well, daily total intake of diet and water, and fluoride level in indoor and outdoor air were investigated, and the daily total intake of fluoride was calculated. The children were divided into 5 subgroups according to the daily total intake of fluoride which were <1.00, 1.00-1.99, 2.00-2.99, 3.00-3.99, ?4.00 mg (per person d)^-1. Children’s IQ and the rate of IQ <80 in the subgroup were calculated.

Results:  Children’s IQ in Xihuai village was significantly higher than that in Wamiao village (100.41 ± 13.00). Children’s IQ decreased and the rate of IQ < 80 increased according to the increasing of daily total intake of fluoride. There were significant dose-response relationship between the daily total intake of fluoride and the children’s IQ (y = -3.519x + 103.310), and the rate of IQ <80 (y = 5.779x -1.347).

Conclusions: High level of fluoride intake may affect the development of cerebrum for infant and adolescent, and would result in lower IQ.

• Related Studies :

  • Fluoride, IQ, and advice on type I and II errors

    A 38-year prospective study of 992 New Zealand children on fluoride (F) and IQ, of whom an uncertain number (0–101) had not received, at age 5 years, additional F with F tablets (taken: 139, not taken: 763, unknown: 90), community water fluoridation (CWF) (lived in CWF area: 891, never lived

  • Assessment of groundwater quality with special reference to fluoride and its impact on IQ of schoolchildren in six villages of the Mundra Region, Kachchh, Gujarat, India

    Sixty groundwater (GW) samples from bore and dug wells averaging 560 feet deep were collected from the six villages of Baroi, Chhasara, Gundala, Mundra, Pragpar, and Zarpara in the semi-arid Mundra region of Kachchh, Gujarat, India. The mean temperature of the GW collection samples was 32.11oC, and the average slightly

  • Fluoride exposure, dopamine relative gene polymorphism and intelligence: A cross-sectional study in China.

    Highlights Urine fluoride was inversely associated with IQ. IQ of children with high-activity MAOA genotype was lower than IQ of those with low-activity or female heterozygote genotype. DAT1 and MAOA gene polymorphism modify the effects of UF on IQ. UF, ANKK1, COMT and MAOA have a high-dimensional interaction on

  • Developmental fluoride neurotoxicity: an updated review.

    Background After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public health. However, this practice results in elevated fluoride intake and has become controversial for two reasons. First, topical fluoride application

  • Using the Raven’s standard progressive matrices to determine the effects of the level of fluoride in drinking water on the intellectual ability of school-age children

    Children, aged 9–10½, from 22 villages in Jing County, Hubei Province, China, with different levels of fluoride in the drinking water were tested for their IQs according to the revised version of Raven’s Standard Progressive Matrices. Among 141 children in villages with 2.1–4.0 ppm F in the drinking water, 34

• Related FAN Content :

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • Fluoride & IQ: 76 Studies

    Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching