Abstract

The study evaluated the effect of commercial preparation of deltamethrin, Butox^®, and fluoride (F^–) co-exposure on the brain antioxidant status and cholinesterase activity in rats. Group A was untreated. Group B was gavaged Butox^®, providing deltamethrin at the dose rate of 1.28?mg per kg body weight per day. Group C was administered F^–, as NaF, in drinking water providing 20?ppm F^–. Group D received both deltamethrin and F^– at the same dosages as groups B and C, respectively. Although, glutathione S-transferase activity was induced only in Butox^® alone treated group, the activities of superoxide dismutase and catalase were inhibited in all treatment groups when compared to the control group. Elevated lipid peroxidation was observed in the groups exposed to F^–. The activity of erythrocyte acetylcholinesterase (AChE) was inhibited in Butox^® treated groups, whereas brain AChE activity was inhibited in all treatment groups. In conclusion, both deltamethrin (given as Butox^®) and F^– inhibit AChE activity and produce oxidative stress in brain with F^– producing more oxidative damage. However, compared to the individual exposures, the co-exposure of these chemicals does not produce any exacerbated alteration in these biochemical parameters.

• Related Studies :

  • Combination of fluoride and endosulfan induced teratogenicity and developmental toxicity in Swiss albino mice exposed during organogenesis.

    The present investigation was conducted to evaluate the teratogenic and developmental toxicity of fluoride and endosulfan alone and in combination in pregnant Swiss albino mice exposed during the organogenetic period (5-14 days) of gestation. Fluoride (25.1 mg/kg body weight in water) and endosulfan (1.8 mg/kg bw by oral intubation) when

  • Toxic effects of deltamethrin and fluoride on antioxidant parameters in rats.

    Toxic effects of the pyrethroid pesticide deltamethrin and water-borne fluoride, alone and in combination, on free radical mediated parameters are reported in rats. Twenty-four healthy adult Wistar rats of both sexes were divided into 4 groups with 6 rats in each group. Group I receiving no treatment served as the

  • Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats

    Nine-six Wistar rats were randomly divided into four groups of 24 rats in each group (female:male = 1:1). Over a period up to 90 days, with one untreated group as controls, the other three groups were administered, respectively, high fluoride (100 mg NaF/L), high arsenic (50 mg As2O3/L), or both

  • Interplay of ROS and behavioral pattern in fluoride exposed Drosophila melanogaster.

    Highlights NaF exposure increases mortality and changes male-female ratio in Drosophila. NaF treatment alters the activities endogenous antioxidant enzymes. Chronic sub-lethal NaF exposure causes increased oxidative damage. NaF decreases brain cell viability and increases DNA damage. NaF exposure alters selected behavioral pattern in Drosophila melanogaster. Reactive oxygen species (ROS) is

  • A correlation between serum vitamin, acetylcholinesterase activity and IQ in children with excessive endemic fluoride exposure in Rajasthan, India

    Fluoride  is  widely  distributed  in  nature  and  a  direct  source  of  adverse  health  effects  in  human  populations.  Fluoride poisoning  attributed  by  long-term  exposure  to  high  levels  of  fluoride  [is] called  fluorosis.  The  present  study was  carried  out among  9-14  years  old  school  children  of Dausa  district,  Rajasthan  India.  The  subjects

• Related FAN Content :

  • Nutrient Deficiencies Enhance Fluoride Toxicity

    It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,

  • Annapolis: Water Fluoridation Linked to Death of Dialysis Patient

    EVENING CAPITAL (Annapolis, Maryland) November 29, 1979 Fluoride Linked to Death by Mary Ann Kryzankowicz Staff Writer Fluoride poisoning has been definitely linked to the death of a 65-year-old kidney dialysis patient who became ill during a blood cleaning process Nov 11. State Medical Examiner Dr. (illegible) Guard has ruled that Lawrence Blake, 65, of Arundel

  • Fluoride & Oxidative Stress

    A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.