Metals such as aluminum and Fluoride have been implicated in the etiology of several neurodegenerative disorders . Resveratrol, a natural polyphenol, exerting a wide range of biological and pharmacological activities including its antioxidative properties against neurodegenerative disorders through its ability to lessen oxidative stress. Rats were divided in to 4 groups. Group – I was served as control. Group – II was intoxicated with Alcl 3 (100 mg/kg b.w) along with Sodium fluoride (10 mg/kg b.w). Group – III was administered with Alcl 3 (100 mg/kg b.w) + Sodium fluoride (10 mg/kg b.w) + resveretrol (30 mg/kg b.w ). Group – IV was administered with resveretrol (30 mg/kg b.w) alone for 8 weeks. The obtained results showed significant oxidative stress induced neuronal damage in cerebral cortex and hippocampus in intoxicated rats where as significant reduction in neuronal damage in the rats administered with resveratrol against aluminium along with fluoride. Hence, the results of the present study reveal that the resveratrol has potential neuroprotective properties to reverse the cortical and hippocampal neuronal damage induced by aluminum and fluoride intoxication.
from Results and Discussion:
The neuronal damage and aggregation was observed in AlCl 3 + NaF treated group when compared to the control group where as less neuronal damage and aggregation was observed when Resveratrol administered along with AlCl 3 + NaF treatment. No morphological variation was observed in Resveratrol alone treated group as compared to the control group.
The amyloid protein plaques were formed in the AlCl 3 +NaF treated group as compared to the control group. The amyloid plaques were not observed in the Resveratrol along with AlCl 3 +NaF treated group as compared to the AlCl 3 +NaF treated group.