Abstract
The elevated fluoride from drinking water impacts on T3, T4 and TSH hormones. The aim was study impacts of drinking water fluoride on T3, T4 and TSH hormones inYGA (Yazd Greater Area). In this case– control study 198 cases and 213 controls were selected. Fluoride was determined by the SPADNS Colorimetric Method. T3, T4 and TSH hormones tested in the Yazd central laboratory by RIA (Radio Immuno Assay) method. The average amount of TSH and T3 hormones based on the levels of fluoride in two concentration levels 0-0.29 and 0.3-0.5 (mg/L) was statistically significant (P?=?0.001 for controls and P?=?0.001 for cases). In multivariate regression logistic analysis, independent variable associated with Hypothyroidism were: gender (odds ratio: 2.5, CI 95%: 1.6-3.9), family history of thyroid disease (odds ratio: 2.7, CI 95%: 1.6-4.6), exercise (odds ratio: 5.34, CI 95%: 3.2-9), Diabetes (odds ratio: 3.7, CI 95%: 1.7-8), Hypertension (odds ratio: 3.2, CI 95%: 1.3-8.2), water consumption (odds ratio: 4, CI 95%: 1.2-14). It was found that fluoride has impacts on TSH, T3 hormones even in the standard concentration of less than 0.5?mg/L. Application of standard household water purification devices was recommended for hypothyroidism.
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Effects of chronic fluorosis on thyroxine, triiodothyronine, and protein-bound iodine in cows
This study was conducted to evaluate the effects of chronic fluorosis in cows on their blood serum levels of thyroxine (T4), triiodothyronine (T3), and protein-bound iodine (PBI). Data collected from twenty cows with chronic fluorosis in the Tendurek Mountain region (altitude about 2000 m) in East Anatolia, Turkey, were compared
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Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride.
Highlights Sodium fluoride exposure from pregnancy to lactation induces thyroid toxicity. This can affect neurodevelopment and induce behavioural changes. Spirulina platensis role in reversing fluoride-induced toxicity was ascertained. Significant protection was exerted by Spirulina The study investigated the role of Spirulina platensis in reversing sodium fluoride-induced thyroid, neurodevelopment and oxidative alterations
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Measurement of the content of T3, T4, and TSH in children in endemic fluorosis areas
The contents of T3, T4, TSH, urine fluoride, and urine iodine in 8-12 year-old children [were measured] in endemic fluorosis areas (water fluoride 3.52 mg/L). The results are: T4 content significantly decreased in the blood. T3 and TSH content was significantly elevated, and there is a positive correlation between the
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Fluorine and thyroid gland function: a review of the literature
The increasing use of fluoride for prevention of dental caries poses the problem as to whether this halogen has antagonistic properties towards iodine, whereby it could hamper the success of iodine prophylaxis of endemic goitre. Review of the literature shows that some authors have found an inhibition by fluoride of
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Effect of long-term fluoride administration on thyroid hormones level blood in rats
The effect of 2 months fluoride administration (0.1 and 1.0 mg daily/rat) on thyroxine and triiodothyronine level in blood and T3-resin uptake ratio was investigated in rats. In addition, free thyroxine index was calculated from serum thyroxine level and T3-resin uptake ratio. It was found that fluoride administration caused: 1.
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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NRC (2006): Fluoride's Impact on the Thyroid Gland
Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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