- Sodium fluoride toxicity in Oryctolagus cunniculus and resulting fluctuations in hematological profile.
- Dose pattern for 5 rabbits in each group 1. Control group without dose, Experimental group I with 10 mg/kg, Experimental group II with 30 mg/kg, Experimental group III with 50 mg/kg.
- Leucocytosis and anemia was observed in affected animals.
Blood is promptly affected by environmental pollutants and toxicants that can cause many metabolic disorders. The high level of fluoride acts as a potential pollutant, insecticide and rodenticide with very high toxicity, associated with the hematological damage. This study aimed to determine the toxicity of Sodium Fluoride on hematological parameters in Oryctolagus cunniculus. Twenty rabbits were acclimatized and divided in to control group and three experimental groups.Experimental group-I, II and III were treated with 10, 30 and 50?mg/kg body weight doses of Sodium Fluoride orally. Various blood parameters such as TEC, Hb, HCT, MCV, MCH, MCHC, TLC and PLT count were investigated. Result findings showed that values of blood indices in experimental groups were significantly lower than the control group. Oneway ANOVA was applied for statistical analysis. The outcomes of the current studies indicated the reduction in RBC counts (anemia), leukocyte count (leukocytopenia), monocytosis, eosinopenia, neutrophilia and thrombocytosis on fluoride intoxication. Hematological disruptions like microcytic hypochromic anemia and decreased leukocyte count may be linked to the inflammatory effects of Sodium Fluoride on lymphatic organs.
Effects of fluoride on the tissue oxidative stress and apoptosis in rats: biochemical assays supported by IR spectroscopy data.
The mechanism underlying the toxicity of fluoride still remains unknown. To investigate the effects of different doses of fluoride on blood and tissue oxidative stress and apoptosis, we exposed male rats to three doses of fluoride (10, 50 and 100ppm in drinking water) for a period of 10 weeks. The
Plasma and water fluoride levels and hyperuricemia among US adolescents.
Background: Evidence obtained thus far on the relationship between exposure to excessive fluoride and serum uric acid levels has been based predominately on experimental animals and the studies have provided mixed results. The present study was to determine a potential relationship between fluoride exposure and uric acid levels in a
Alteration of paraoxonase, arylesterase and lactonase activities in people around fluoride endemic area of Tamil Nadu, India.
BACKGROUND: Toxicity due to excess fluoride concentration in drinking water is of great concern in people who rely only on the ground water as their water source in many region of the world. METHODS: We collected samples and examined the toxicity of fluoride in a population residing at Salem, Dharmapuri and
Drinking water fluoride and blood pressure: an environmental study.
The relationship between intakes of fluoride (F) from drinking water and blood pressure has not yet been reported. We examined the relationship of F in ground water resources (GWRs) of Iran with the blood pressure of Iranian population in an ecologic study. The mean F data of the GWRs (as
Changes in the concentration of fluoride in the serum and bones of female rats with streptozotocin induced diabetes.
The aim of this study was to determine if streptozotocin-induced diabetes in rats as a model for Type-1 human diabetes causes changes in the levels of fluoride (F) and biogenic elements in the bones and serum in the initial stage of the disease. Twenty-two female Wistar rats were given streptozotocin
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