The fluoride content of drinking water is directly correlated with the serum and saliva fluoride. Serum fluoride levels are also directly related to those of saliva, but not to urinary fluoride.
These interrelations are so close that a mathematical formula can be devised for the calculation of fluoride in body fluids. For instance, a sample of saliva may serve for the quantification of serum fluoride. Whereas these interrelations are observed in general population groups they do not always apply to individuals.
Biomarkers for the Assessment of Fluoride Exposure in Children.
Due to practical difficulties in quantifying fluoride exposure, the ability of various biomarkers to predict exposure has been investigated previously. However, the results are inadequate for validation of their application and usefulness. This study aimed to investigate the association between contemporary/recent biomarkers of fluoride exposure and total daily fluoride intake
Plasma and water fluoride levels and hyperuricemia among adolescents: A cross-sectional study of a nationally representative sample of the United States for 2013–2016.
Highlights Relatively low levels of fluoride exposure in US adolescents but with wide ranges. Dose-dependent increase in prevalence of hyperuricemia with increasing fluoride levels. Significant associations between plasma and water fluoride and hyperuricemia. A positive relationship between water and plasma fluoride concentrations. Potential role of chronic fluoride exposure in
Fluoride metabolism: its significance in water fluoridation.
Excerpt The purpose of this report is the review of the present knowledge of the metabolism of fluorides, particularly in the human body, and the use of this knowledge in estimating the factors of safety in water fluoridation. In this discussion, many of the biological effects of fluorides (purported or well-established)
The association of fluoride in drinking water with serum calcium, vitamin D and parathyroid hormone in pregnant women and newborn infants.
Background: Chronic exposure to fluoride in drinking water causes an increase in plasma fluoride levels that is related to a reduction in calcium transport across the renal tubule endoplasmic reticulum and plasma membrane. In the present study, it was hypothesised that varying levels of fluoride present in drinking
Analysis of the MicroRNA Profile by Sequencing in Ovarian Granular Cells from Women Suffering Fluorosis with Reproductive Dysfunction.
Excessive intake of fluoride may cause female reproductive dysfunction but pathological mechanism is unclear. The miRNAs in follicular fluid are a class of small non-coding RNAs from granulosa cells. The aim of this study is to examine the differential expressions of miRNAs in ovarian granulosa cells from women suffering from
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