The fluoride content of drinking water is directly correlated with the serum and saliva fluoride. Serum fluoride levels are also directly related to those of saliva, but not to urinary fluoride.
These interrelations are so close that a mathematical formula can be devised for the calculation of fluoride in body fluids. For instance, a sample of saliva may serve for the quantification of serum fluoride. Whereas these interrelations are observed in general population groups they do not always apply to individuals.
Biomarkers for the Assessment of Fluoride Exposure in Children.
Due to practical difficulties in quantifying fluoride exposure, the ability of various biomarkers to predict exposure has been investigated previously. However, the results are inadequate for validation of their application and usefulness. This study aimed to investigate the association between contemporary/recent biomarkers of fluoride exposure and total daily fluoride intake
Plasma and water fluoride levels and hyperuricemia among US adolescents.
Background: Evidence obtained thus far on the relationship between exposure to excessive fluoride and serum uric acid levels has been based predominately on experimental animals and the studies have provided mixed results. The present study was to determine a potential relationship between fluoride exposure and uric acid levels in a
Studies on fluorosis in Mehsana District of North Gujarat.
A survey was conducted in eighteen fluoride endemic villages in Mehsana District of North Gujarat (India). The individuals afflicted with fluorosis were examined for apparent mottled teeth and skeletal complications. Samples of urine and blood of these individuals along with drinking water were collected and compared with samples obtained from
Studies on fluoride concentrations in human submandibular/sublingual saliva and their relation to flow rate and plasma fluoride levels
Submandibular/sublingual saliva and blood were collected from five subjects after ingestion of 1 mg fluoride as NaF. An individual collection device, made from a silicone impression material, was used to collect the saliva in 10-minute samples, before and during 2 hr after the fluoride intake. In two separate experiments on
Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis.
Excessive taking fluoride (F) causes severe damage to reproductive system through stimulation of apoptosis and oxidant stress. Selenium (Se) may promote anti-oxidant enzymes and invert cell apoptosis. The aim of this study was to investigate the effect of Se on peripheral blood mononuclear cell (PBMC) apoptosis and oxidant stress in
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