Abstract

Highlights

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    This study reports the protective effects of tamarind ingestion against fluoride induced changes on motor activity and metabolism of Gastrocnemius muscle (GM) of rats. The male Wistar rats were divided into four groups - control, fluoride treated i.p. (20 mg NaF/Kg bw) and Tamarind (Tamarindus indicus III -150mg/kg bw and

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    Background: Fluoride is an excitotoxin challenging the excitatory receptors and activate them continuously and also in proliferation of reactive oxygen and nitrogen species leading to neurodegeneration and its associated dysfunction. Chronic exposure to 20ppm sodium fluoride to pregnant rats is proven to be neurotoxic for the developing pups. Carica papaya

  • Fluoride sensitivity in freshwater snail, Bellamya bengalensis (Lamarck, 1882): An integrative biomarker response assessment of behavioral indices, oxygen consumption, haemocyte and tissue protein levels under environmentally relevant exposure concentrations.

    Highlights Responses in NaF-exposed freshwater snail, Bellamya bengalensis was estimated. Mortality increased with elevated fluoride concentrations and increasing exposure period. Altered behavior and lowered oxygen consumption were concentration-dependent. Decreased haemocyte count could impact respiratory capacity. Reduced protein content in hepatopancreas indicate impaired protein synthesis. There is limited information on fluoride

  • The effect of sodium fluoride on responses to various central nervous system agents in rats

    Rats given sodium fluoride at 10 mg/kg daily by the intraperitoneal route were more sensitive to the convulsant action of strychnine and pentylenetetrazol and to electroshock. This increase in sensitivity to CNS stimulation was observed also in two other groups of rats which were given a diet with added sodium

  • Quercetin ameliorates oxidative stress, neural damage of brain and behavioral impairment of rat with fluoride exposure.

    Excess fluoride causing fluorosis, can enter in to brain, disturb oxidative status and induce neural damage. Quercetin, antioxidant flavonoid stabilizes oxidative milieu of brain by quenching free radicals. The present study aimed to report ameliorative effect of quercetin on NaF induced oxidative stress, histological alterations in the brain and behavioural

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