- A total of 64% samples exceeded the standard limit of fluoride set by World Health Organization/Bureau of Indian Standards.
- The estimated exposure doses (EDs) were 0.69, 0.31 and 0.12 mg/kg/day for infants, children, and adults, respectively.
- The HQ was more than 1 for infants and children at all sites while it was greater than 1in 71% of adults.
- There were potential non-carcinogenic effects on infants and children highly exposed to fluoride in the study area.
Fluoride (F– ), a harmful compound if present in high concentration, is typically found in groundwater. It is important to investigate the F– concentrations in groundwaters of areas where individuals use groundwater for drinking purposes. The objectives of this study were: (a) to estimate the F– exposure, and (b) to assess the non-carcinogenic risk through consumption of groundwater among urban population (different age groups) of Agra city. A total of 28 groundwater samples were collected from Agra city in May 2016, which comprised 22 samples from hand pump and 6 samples from tube wells from shallow aquifers at different sites. The F– concentrations varied from 0.90 to 4.12 mg/L with an average value of 1.88 mg/L. The results obtained reveal that about 64% of the samples exceeded the F– permissible limit of 1.5 mg/L. Nevertheless, 32% of the samples were well within the WHO drinking water guidelines and 3.5% of the samples from the groundwater were below the 1.0 mg/L threshold. The maximum estimated exposure doses were 0.69, 0.31 and 0.12 mg/kg/day for infants, children and adults, respectively. A dental fluorosis becomes evident when the results obtained are compared with an oral reference dose of 0.06 mg/kg/day. The hazard quotient (HQ) was found to be more than 1 for infants and children in all the studied areas which indicates that young consumers are more vulnerable to non-carcinogenic risk due to exposure of F–. On the other hand, the adults at about 71% of the sampled sites may be victims of non-carcinogenic risk. From the results obtained in this study, it is recommended that there be implementation of the appropriate remediation for defluoridation of water to circumvent the population from the probable health risks of F–.
Risk of fluorosis associated with infant formulas prepared with bottled water.
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Dietary fluoride intake from infant and toddler formulas in Poland.
Risk of enamel fluorosis associated with excessive fluoride intake during infancy and early childhood has been widely reported in literature. Results of several studies indicate that infant formula consumption, especially in the form of powdered concentrate, may appreciably increase children's fluoride exposure in optimally fluoridated communities. The aim of the
Comparison of recommended and actual mean intakes of fluoride by Canadians
The findings of two separate 1993 reports, one of the actual intake of fluoride by Canadians and the other on their recommended fluoride intake, are summarized and compared. Recent increases in very mild and mild dental fluorosis suggest that the gap between current fluoride intake and recommended intake is narrowing. The daily swallowing of fluoride dentifrice makes
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