- A large-scale study on school-age children’s health in a Chinese fluorosis area.
- Low-to-moderate fluoride and children’s anthropometric measurements were assessed.
- Fluoride exposure is related to increased BMI z-score and prevalence of overweight.
- The significant associations were differed by gender and mainly observed in girls.
- Associations were stronger among children of fathers with lower educational status.
High fluoride exposure has been related to harmful health effects, but the impacts of low-to-moderate fluoride on child growth and obesity-related outcomes remain unclear. We performed a large-scale cross-sectional study to examine the association between low-to-moderate fluoride in drinking water and anthropometric measures among Chinese school-age children. We recruited 2430 resident children 7–13 years of age, randomly from low-to-moderate fluorosis areas of Baodi District in Tianjin, China. We analyzed the fluoride contents in drinking water and urine samples using the national standardized ion selective electrode method. Multivariable linear and logistic analyses were used to assess the relationships between fluoride exposure and age- and sex-standardized height, weight and body mass index (BMI) z-scores, and childhood overweight/obesity (BMI z-score>1). In adjusted models, each log unit (roughly 10-fold) increase in urinary fluoride concentration was associated with a 0.136 unit increase in weight z-score (95% CI: 0.039, 0.233), a 0.186 unit increase in BMI z-score (95% CI: 0.058, 0.314), and a 1.304-fold increased odds of overweight/obesity (95% CI: 1.062, 1.602). These associations were stronger in girls than in boys (Pinteraction=0.016), and children of fathers with lower education levels were more vulnerable to fluoride (Pinteraction=0.056). Each log unit (roughly 10-fold) increase in water fluoride concentration was associated with a 0.129 unit increase in height z-score (95% CI: 0.005, 0.254), but not with other anthropometric measures. Our results suggest low-to-moderate fluoride exposure is associated with overweight and obesity in children. Gender and paternal education level may modify the relationship.
Evaluation of vascular and kidney injury biomarkers in Mexican children exposed to inorganic fluoride.
Highlights The relationship of child F exposure with vascular and kidney injury was assessed. The F exposure in children was partially explained by water F levels. Overall, the results were unable to elucidate kidney damage by F exposure. Childhood F exposure was associated with atherosclerotic biomarkers. Decreased serum and urine
Evaluation of a fluorosis prevention educational program: A randomized field trial.
Background: A 2-group randomized field trial was conducted to evaluate the impact of a fluorosis educational preventive program in mother´s knowledge and practices, and on the urine fluoride concentration of their preschool children. Material and Methods: A group of 139 mother-child pairs participated in the study. Randomly, children were assigned to an intervention
Fractional urinary fluoride excretion and nail fluoride concentrations in normal, wasted and stunted 4-5 year-old children in Nepal.
Highlights It is suggested that undernourished children may be more likely develop dental fluorosis. Fluoride intake and excretion were measured in normal, wasted and stunted children. Proportion of ingested fluoride excreted via urine was not related to nutritional status. Nutritional status affected fingernail- but not toenail- fluoride concentration. Abstract Introduction It has
Association of Dietary Calcium Intake with Dental, Skeletal and Non-Skeletal Fluorosis among Women in the Ethiopian Rift Valley.
Fluorosis is a major public health problem in the Rift Valley of Ethiopia. Low calcium (Ca) intake may worsen fluorosis symptoms. We assessed the occurrence of fluorosis symptoms among women living in high-fluoride (F) communities in South Ethiopia and their associations with dietary Ca intake. Women (n = 270) from
WITHDRAWN: Co-exposure effects of arsenic and fluoride on intelligence and oxidative stress in school-aged children: a cohort study.
This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. as of November 6, 2020 Highlights Pioneer biomonitoring study on rural children to address As and F- co-exposure. High dental Fluorosis found in relation to urinary As and F- levels in
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