Abstract
Purpose: This study investigated the potential association between fluoride exposure and behavior problems in children, as well as the prevalence of and risk factors for fluorosis.
Methods: Children between the ages of 7 and 1 years (N = 197) were included in the study and were examined for dental fluorosis using the Modified Dean’s Index. Parents of subjects completed and returned three questionnaires which investigated their children’s history of exposures to fluoride, social and medical backgrounds, and behavior using the Child Behavior Checklist (CBCL).
Results: Sixty-nine percent of the study participants demonstrated fluorosis with very mild fluorosis being the most common (39%), while 13% demonstrated moderate to severe fluorosis. Using a summation of the Modified Dean’s index (Sum of 8), we divided the children into high fluorosis (HF) and low fluorosis (LF) groups. These groups were compared to each other with respect to fluoride exposures and behavior.
Conclusion: Although there was no association between the fluoride exposures in aggregate and fluorosis, there was a significant association between supplemental fluoride exposure from ages 0-3 years and fluorosis. There was no association between behavior problems and dental fluorosis in this population.
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Investigation of Intelligence Levels of Children of 8 to 12 Years of Age in Coal Burning-Related Endemic Fluorosis Areas.
Objective: To investigate the relationship between age, dental fluorosis and intelligence in children aged 8-12 in coal-burning fluorosis (CBF) area, Guizhou province. Methods: A cross-sectional study was conducted to investigate the prevalence of dental fluorosis and intellectual level in 284 children (n=167 for CBF area, n=120 for control are) aged 8-
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Fluoride exposure during early adolescence and its association with internalizing symptoms.
Highlights Adolescents with elevated urinary fluoride concentrations exhibit more somatization symptoms. Males may represent an at-risk population for fluoride-related internalizing behaviors. While somatization is typically comorbid with anxiety and depression, fluoride concentrations were not associated with increased depressive or anxiety symptoms. Background Early, chronic, low-level fluoride exposure has been linked to
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Sodium Butyrate Ameliorates Fluorosis-Induced Neurotoxicity by Regulating Hippocampal Glycolysis In Vivo.
Fluorosis can induce neurotoxicity. Sodium butyrate (SB), a histone deacetylase inhibitor, has important research potential in correcting glucose metabolism disorders and is widely used in a variety of neurological diseases and metabolic diseases, but it is not yet known whether it plays a role in combating fluoride-induced neurotoxicity. This study
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Exposure to fluoridated public water supplies and child health and behaviour.
The relationship between duration of exposure to fluoridated public water supplies and measures of child health and behaviour was studied for a birth cohort of Christchurch children. This study showed no association between exposure to fluoridated water and a large range of measures of child health and behaviour taken during
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Protections against toxicity in the brains of rat with chronic fluorosis and primary neurons exposed to fluoride by resveratrol involves nicotinic acetylcholine receptors.
Highlights Fluorosis decreased learning and memory of rats and increased oxidative stress. The changes above may be associated with the lower expressions of a7 and a4 nAChRs. RSV attenuated the toxic effect by fluorosis, which might involve stimulating nAChRs. Protection of Resveratrol (RSV) against the neurotoxicity induced by high level of
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Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
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Dental Fluorosis Is a "Hypo-mineralization" of Enamel
Teeth with fluorosis have an increase in porosity in the subsurface enamel ("hypomineralization"). The increased porosity of enamel found in fluorosis is a result of a fluoride-induced impairment in the clearance of proteins (amelogenins) from the developing teeth. Despite over 50 years of research, the exact mechanism by which fluoride impairs amelogin
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Dental Fluorosis in the U.S. 1950-2004
Before the widespread use of fluoride in dentistry, dental fluorosis was rarely found in western countries. Today, with virtually every toothpaste now containing fluoride, and most U.S. water supplies containing fluoride chemicals, dental fluorosis rates have reached unprecedented levels. In the 1950s, it was estimated that only 10% of children in
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