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• Related Studies :

  • Modified expression of extracellular signal-regulated protein kinase signal transduction in rat brains and changed capacity of learning and memory of rats with chronic fluorosis.

    Objective: To investigate the expression of extracellular signal-regulated protein kinase (ERK1/2) pathway in rat brains with fluorosis and the effects of fluoride on learning and memory of the rats, and to reveal the mechanisms of damaged nervous system resulted from the toxicity of the ion. Methods: Seventy-two SD rats were divided

  • Fluoride toxicity and status of serum thyroid hormones, brain histopathology, and learning memory in rats: a multigenerational assessment.

    High-fluoride (100 and 200 ppm) water was administered to rats orally to study the fluoride-induced changes on the thyroid hormone status, the histopathology of discrete brain regions, the acetylcholine esterase activity, and the learning and memory abilities in multigeneration rats. Significant decrease in the serum-free thyroxine (FT4) and free triiodothyronine (FT3)

  • The analog of Ginkgo biloba extract 761 is a protective factor of cognitive impairment induced by chronic fluorosis.

    Ginkgo biloba extract EGb761 is widely used to treat patients with learning and memory impairment in Alzheimer's disease and Parkinson's disease in China. However, it is not yet clear whether the analog of EGb761 (EGb) has a protective effect on the learning and memory damage induced by chronic fluorosis. In

  • Effect of coal-burning endemic fluorosis on children's physical development and intellectual level

    Objective To investigate the effect of coal-burning endemic fluorosis on children's physical development and intellectual level so as to provide data support for the protection of children's healthy growth in fluorosis areas. Methods Ninety children with coal-burning endemic fluorosis were selected for the study, which were divided into heavy fluorosis area group, middle

  • Chronic fluorine intoxication from drinking water

    Summary The case of ? 35-year-old woman is described presenting stiffness and severe pain in the spine, gastric disturbances, stomatitis, paresthesias in legs and arms, especially in the u1nar nerve area, loss of mental acuity, visual disturbances and extreme general malaise. On1y ? few clear-cut objective findings were noted, namely: decreased muscular

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