Abstract

SUMMARY: In an extension of previous work on fluoride (F) toxicity in a group of 80 Swiss albino mice, the mitigating effects of polyphenols in black tea on the F-induced increase in glycogen, cholesterol, and total lipids in the cerebral hemisphere (CH), cerebellum (CB), and medulla oblongata (MO) regions of the brain were studied. Oral administration of sodium fluoride (6 and 12 mg NaF/kg bw/day) to the mice for 30 days resulted in a significant dose-dependent increase in the parameters studied. Withdrawal of treatment for 30 days caused significant but only partial recovery. Administration of a 2% black tea infusion alone for 30 days did not cause any significant alteration. However, concurrent administration of NaF and black tea infusion for 30 days produced significant mitigation in all the parameters.

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