Goitre and Fluorosis in Kenya

Role of nitric oxide and vascular endothelial growth factor in fluoride-induced goitrogenesis in rats

Endemic fluorosis is a serious problem in public health. Previous studies have indicated that patients with thyroid goiters usually live in fluoride-affected areas. However, the mechanism of goitrogenesis caused independently by fluoride is still unclear. The principle objective of this study was to investigate the possible roles of nitric oxide

Functional state of thyroid under extended exposure to fluorides

The issue of specific effect of fluorine on the thyroid in humans remains debatable. There is no doubt, however, that cases of experimental fluorosis are characterized by specific toxicity of fluorine to the thyroid. The hypoactivity of thyroid epithelium is observed, the destructive changes in the follicular cells increasing with the

[Premature aging of the population in the zone of endemic goiter.]

Original title: Prezhdevremennoe starenie naseleniya v zone rasprostraneniya endemicheskogo zoba. No Abstract  

Incidence of simple goiter in areas of endemic fluorosis in Nalgonda District, Andra Pradesh, India

The results of analyses of the mineral content of drinking water from three Indian villages with endemic fluorosis surveyed for the incidence of thyroid enlargement are reported. With the possible exception of temporary thyroid enlargement encountered in pubertal subjects (type b), no relation was found between the incidence of endemic goiter

Fluoride, Water Hardness, and Endemic Goitre

Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.

The Relationship Between Fluoride Exposure & Goitre in South Africa

As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.

Fluoride & Goiter

Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the

Fluorine in the Aetiology of Endemic Goitre

The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.

Fluoride Exposure Aggravates the Impact of Iodine Deficiency

A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and