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    Blood and urine were collected from 72 cows in six dairy herds with varying severity of dental and bone fluorotic lesions. Urinary fluoride averaged 5.13 ppm and ranged from 1.04 to 15.7 ppm fluoride. Thyroxine and triiodothyronine in serum decreased with increasing urinary fluoride, eosinophils increased, and cholesterol tended to

  • Effects of fluoride on the ultrastructure of glandular epithelial cells of human fetuses.

    Objective   Ultrastructural changes in epithelial cells of livers, adrenal glands, and thyroid glands of human fetuses from a fluorosis-endemic area were observed to provide an experimental basis for investigating the mechanism by which fluoride causes cellular damage. Methods   10 human fetuses in a fluorosis-endemic area were collected, whose mothers all had

  • Review of the Bartlett-Cameron survey: a ten year fluoride study.

    Analysis of the data produced the following conclusions: 1.  As was expected, dental fluorosis was significantly greater in Bartlett than in Cameron (all of the participants born and in continuous residence in Bartlett during the tooth formative period exhibited positive evidence of dental fluorosis). 2.  The incidence of cardiovascular disease was higher

  • A systematic analysis on possibility of water fluoridation causing hypothyroidism.

    Background: Community water fluoridation is widely used worldwide and its role in preventive dental health care is well established. However, there is sufficient evidence of the ill effects of excessive fluoride content in water, causing skeletal and dental fluorosis. Alongside, there was also extraskeletal and dental manifestations of excessive fluorides

  • Effects of high iodine and high fluorine on children’s intelligence and thyroid function.

    Objective: Try to find out the effects of high iodine and high fluorine on children’s intelligence and thyroid function. Methods: We selected in Qingyun County the Lidian Primary School, where the iodine and fluorine in the water are relatively high in concentration as the investigative point and Dading Primary School where the iodine and

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  • Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?

    When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.

  • Fluorine in the Aetiology of Endemic Goitre

    The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.

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    Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as

  • Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides

    Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.

  • The Relationship Between Fluoride Exposure & Goitre in South Africa

    As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.