Abstract

Summary

Our results suggest that orally administered sodium fluoride enters liver and brain. The blood-brain barrier fails to exclude the fluoride ion from nerve tissue. That fluoride ions also readily pass the placental barrier has been repeatedly demonstrated (9). Fluoride-levels in brain reach a maximum approximately two hours after it has been administered, whereas accumulation in liver continues for at least three hours.

• Related Studies :

  • Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity – A review.

    Highlights Fluoride exposure induces mitochondrial function dysfunction. Fluoride exposure mediates organs injury involved in apoptosis and autophagy. Fluoride exposure induces inflammatory reaction. Fluoride exposure results changes in intestinal microbial abundance. Fluoride is an important trace element in the living body. A suitable amount of fluoride has a beneficial effect on

  • Evaluation of the toxicity of fluorine in Antarctic krill on soft tissues of Wistar rats

    Antarctic krill are a potential food source for humans and animals, but krill are known to contain high levels of fluorine (F). In this study, we investigated the toxicity of F in Antarctic krill using Wistar rats. There were three experimental groups: The control group were fed a basal diet,

  • New data for the validation of the mean daily maximum permissible concentration of hydrogen fluoride in atmospheric air

    1.  Round-the-clock exposure to hydrogen fluoride concentrations of 0.10 and 0.03 mg/m3 causes inhibition in the central nervous system, decreases the activity of a number of enzymes, impairs the phosphorus-calcium metabolism, and causes the accumulation of fluorine in the body and damage to the internal organs and bone tissue. 2.  A

  • Clinical features of early stages of occupational fluorosis under the combined and joint effect of production factors

    Over 1000 workers of hydrofluoric and cryolite enterprises and electrolysis shops of aluminium enterprises were examined. Subjects exposed to soluble hydrofluorides presented in the early stage of chronic intoxication with a variety of syndromes, that was characteristic of intoxication with poisons of general toxic action with involvement of hepatobiliary, digestive,

  • Chronic exposure to environmentally relevant concentration of fluoride alters Ogg1 and Rad51 expressions in mice: Involvement of epigenetic regulation.

    Highlights Almost 200 million people all over the world are facing dreadful effects of fluoride. Mice were treated orally with environmentally relevant concentration of fluoride for 8 months. Fluoride treatment resulted into histopathology, oxidative stress response and transcriptional alterations of Ogg1 and Rad51. DNA fragmentations and apoptosis induction was

• Related FAN Content :

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride & IQ: 76 Studies

    • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching