The study was conducted on 25 healthy women residing in optimum fluoride areas, who were to deliver normally through vaginal route, to correlate the maternal and cord plasma fluoride levels and evaluate the placental transfer of fluoride. A wide variation was found in the maternal and cord plasma fluoride levels. In only 8 percent of the cases the fluoride levels in cord plasma were higher than maternal plasma. It was deduced that the placenta allows passive diffusion of fluoride from mother to foetus and does not act as a barrier.
Pharmacokinetics of fluoride in human adults: The effect of exercise.
Highlights This human study adds to understanding of the effects of exercise on fluoride (F) metabolism. F pharmacokinetics following no, light, moderate and vigorous exercise were compared in adults. Moderate exercise resulted in the highest maximum plasma F concentration (Cmax). Area Under the Curve for plasma F concentration against
Serum kinetics of ionized fluoride and abnormalities of urinary parameters after single intravenous injection of hydrofluoric acid in rats.
Harmful systemic effects were studied 1 hour after acute sub-lethal exposure to hydrofluoric acid (HFA) in previous study. This study was designed to investigate the early dynamic state of F in blood and urine in rats as a model of accidental occupational exposure to HFA. It was also designed to
Analysis of the MicroRNA Profile by Sequencing in Ovarian Granular Cells from Women Suffering Fluorosis with Reproductive Dysfunction.
Excessive intake of fluoride may cause female reproductive dysfunction but pathological mechanism is unclear. The miRNAs in follicular fluid are a class of small non-coding RNAs from granulosa cells. The aim of this study is to examine the differential expressions of miRNAs in ovarian granulosa cells from women suffering from
Serum inorganic fluoride: changes related to previous fluoride intake, renal function and bone resorption
1. Inorganic fluoride concentrations were determined in serum and urine specimens of 24 subjects receiving a standardized low fluoride intake. Serum fluoride was directly correlated with previous intake and appeared to reflect bone fluoride stores. 2. A positive correlation between creatinine and fluoride clearance was found. However, striking reductions in
Fluoride in whole saliva, parotid ductal saliva and plasma in children
The purpose was to investigate the relation between fluoride concentrations in whole saliva, parotid ductal saliva, and plasma in 5- to 10-year-old children (n = 17). Two stimulated whole-saliva samples were obtained from each child. Before the second sample was obtained, each child rinsed several times with a total of
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