Transplacental passage of fluorides was studied in 25 randomly selected neonates. Blood samples collected simultaneously from the mother and the umbilical cord showed that average fluoride concentration in the cord blood was 60% of that in mother’s blood. When concentration in the mother’s blood exceeded 0.4 ppm, the placenta acted as a selective barrier.
Fluoride metabolism: its significance in water fluoridation.
Excerpt The purpose of this report is the review of the present knowledge of the metabolism of fluorides, particularly in the human body, and the use of this knowledge in estimating the factors of safety in water fluoridation. In this discussion, many of the biological effects of fluorides (purported or well-established)
Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016.
Highlights Plasma fluoride concentrations are associated with kidney and liver parameters among United States (U.S.) adolescents Higher water fluoride concentrations are associated with lower blood urea nitrogen among U.S. adolescents Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents Altered kidney and/or liver
Pharmacokinetics of fluoride in human adults: The effect of exercise.
Highlights This human study adds to understanding of the effects of exercise on fluoride (F) metabolism. F pharmacokinetics following no, light, moderate and vigorous exercise were compared in adults. Moderate exercise resulted in the highest maximum plasma F concentration (Cmax). Area Under the Curve for plasma F concentration against
The impact of sevoflurane anesthesia on postoperative renal function: a systematic review and meta-analysis of randomized-controlled trials.
Purpose: Renal damage secondary to fluoride ions and compound A (CpdA) after sevoflurane anesthesia remains unclear. For safety reasons, some countries still recommend minimum fresh-gas flows (FGFs) with sevoflurane. We review the evidence regarding the intraoperative use of sevoflurane for anesthesia maintenance and postoperative renal function compared with
High fluoride exposure in hemodialysis patients
The observation of higher plasma flouride levels in our hemodialysis (HD) patients than our continuous ambulatory peritoneal dialysis (CAPD) patients (4.0 +/- 0.5 mumol/L [n = 17] v 2.5 +/- 0.3 mumol/L [n = 17], P less than 0.005) prompted an evaluation of fluoride metabolism during HD. We found that
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