Transplacental passage of fluorides was studied in 25 randomly selected neonates. Blood samples collected simultaneously from the mother and the umbilical cord showed that average fluoride concentration in the cord blood was 60% of that in mother’s blood. When concentration in the mother’s blood exceeded 0.4 ppm, the placenta acted as a selective barrier.
Serum fluoride concentrations in renal insufficiency
In an area with non-fluoridated water (F content, 0.061 ppm), serum fluoride concentrations as measured with an ion specific electrode were as follows: controls (N = 13), 0.0127 ppm + 0.0057 (mean + SD); renal insufficiency (N = 10), 0.0452 ppm + 0.0151; chronic hemodialysis (N = 11), 0.0424 +
Fluoride metabolism: its significance in water fluoridation.
Excerpt The purpose of this report is the review of the present knowledge of the metabolism of fluorides, particularly in the human body, and the use of this knowledge in estimating the factors of safety in water fluoridation. In this discussion, many of the biological effects of fluorides (purported or well-established)
Fluoride exposure during pregnancy and lactation triggers oxidative stress and molecular changes in hippocampus of offspring rats.
Highlights Fluoride exposure indirectly increased the levels of F in the offspring's plasma. Fluorine exposure promoted biochemical imbalance in the offspring's hippocampus. The 10 mgF/L and 50 mgF/L groups showed an overexpression of the neurotrophin BDNF. In exposed groups modulation of the proteomic profile of the offspring. Proteins associated
Plasma and water fluoride levels and hyperuricemia among adolescents: A cross-sectional study of a nationally representative sample of the United States for 2013–2016.
Highlights Relatively low levels of fluoride exposure in US adolescents but with wide ranges. Dose-dependent increase in prevalence of hyperuricemia with increasing fluoride levels. Significant associations between plasma and water fluoride and hyperuricemia. A positive relationship between water and plasma fluoride concentrations. Potential role of chronic fluoride exposure in
Ionic plasma fluoride concentrations related to some diseases in patients from a fluoridated community
Little data is available concerning the relationship between variations in ionic plasma fluoride (IPF) concentrations and some diseases, and that which exists is inconclusive. The effect of renal insufficiency is known best, but the relationship between IPF levels and some oedematous diseases and diabetes has hardly been studied at all
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