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Developmental Fluoride Neurotoxicity: Choi et al. Respond
Sabour and Ghorbani’s comments about the reported mean difference in IQ (intelligence quotient) scores reported in our article (Choi et al. 2012) suggest a misunderstanding of the scale unit we used and the public health significance of even a small decrease in the average IQ associated with exposure. We appreciate
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Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells.
Highlights Fluoride induced apoptosis in SH-SY5Y cells. Fluoride induced apoptosis via activating mitochondrial p53 apoptotic pathway. Fluoride inhibited SIRT1 deacetylase activity to activate p53. SIRT1 is a promising target to protect against fluoride-induced neurotoxicity. There has been a great concern about the neurotoxicity of fluoride since it can pass through the
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Fluoride concentrations in the pineal gland, brain and bone of goosander (Mergus merganser) and its prey in Odra River estuary in Poland
The aim of the study was to investigate fluoride concentrations in bone, brain and pineal gland of goosander Mergus merganser wintering in the Odra estuary (Poland) as well as in fish originating from its digestive tract. The fluoride concentrations were determined with potentiometric method. Medians of concentrations in goosander had
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Brain mapping of mentally retarded children in high-fluoride regions
On the basis of routine EEG, this article used mapping technologies to conduct research on the brain electrical activities of mentally retarded children in high-fluoride regions. Results showed that the O energy percentages in the central, parietal, occipital, and left temporal areas of the mentally retarded group were significantly higher
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Fluoride Exposure and Concurrent Cognitive Outcomes in 7-15 Year Old Children from Mexico City, Mexico.
BACKGROUND: Recent studies have reported an inverse association between fluoride exposure and IQ in children, but most were ecological in design. Few involved personal measures of exposure or adjusted for confounders. METHODS: This study utilized archived urine samples and data from offspring who participated in the Early Life Exposures in Mexico
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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Fluoride & IQ: 67 Studies
As of May 2020, a total of 75 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 67 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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