Excerpts
In an attempt to find the reason why the anaerobic breakdown of glucose in brain is less in poliomyelitis, experiments were performed using sodium fluoride as an inhibitor (Table II). The percentage inhibition resulting from fluoride was consistently higher in the normal than in the infected brain, particularly with lower concentrations of fluoride. The residual glycolysis in poliomyelitic brain treated with fluoride was equal to the glycolysis in normal brain with fluoride in every experiment. One of the major effects of fluoride is to inhibit glycolysis at the stage of breakdown of phosphoglycerate to phosphopyruvate. In contrast to the results with fluoride, preliminary experiments indicate that monoiodoacetate exerts an equal inhibitory effect on anaerobic glycolysis of normal and poliomyelitic brain suspensions…
TABLE II
The Effect of Sodium Fluoride on Anaerobic Glycolysis…
SUMMARY
1. During paralysis, the brain of the mouse infected with poliomyelitis virus shows on test after mincing a decrease in anaerobic glycolysis with no significant change in oxygen utilization. The decrease in anaerobic glycolysis varies from 5 per cent to 50 per cent.
2. Sodium fluoride produces a greater inhibition of anaerobic glycolysis in normal than in poliomyelitic brain…
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Determination of the contents of amino-acid and monoamine neurotransmitters in fetal brains from a fluorosis-endemic area.
The contents of five types of amino-acid neurotransmitters and three types of monoamine neurotransmitters in the brains of fetuses aborted through induced labor in a chronic fluorosis-endemic area were determined. Findings revealed that the content of the excitatory amino acid, aspartic acid, was significantly lower than in the fetuses from
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Fluorine Intoxication: A Clinical-Hygienic Study with a Review of the Literature and Some Experimental Investigations
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Low glucose utilization and neurodegenerative changes caused by sodium fluoride exposure in rat's Developmental Brain.
Fluorine, a toxic and reactive element, is widely prevalent throughout the environment and can induce toxicity when absorbed into the body. This study was to explore the possible mechanisms of developmental neurotoxicity in rats treated with different levels of sodium fluoride (NaF). The rats' intelligence, as well as changes in
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Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat
BACKGROUND: Sodium fluoride (NaF) intoxication is associated with oxidative stress and altered antioxidant defense mechanism. The present study was carried out to evaluate the potential protective role of blackberry and quercetin (Q) against NaF-induced oxidative stress and histological changes in liver, kidney, testis and brain tissues of rats. METHODS: The rats
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Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
Background: Structural brain abnormalities in newborn animals after prolonged exposure to all routinely used general anaesthetics have raised substantial concerns for similar effects occurring in millions of children undergoing surgeries annually. Combining a general anaesthetic with non-injurious sedatives may provide a safer anaesthetic technique. We tested dexmedetomidine as a mitigating
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride's Effect on Fetal Brain
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Fluoride & IQ: 76 Studies
• As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure
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