Abstract

The pilot study is conducted using 30 adult albino rats (200-250gm). They were divided into one control and one experimental group. Group 1 is Control (Ctrl), which received food and water ad-libitum, experimental group received, 20 ppm of sodium fluoride (NaF) for 7 weeks. The body weights and physical activity was significantly reduced in experimental group, whereas fluoride levels of hippocampus, was greatly increased. Light microscopy of the hippocampus, showed reduced neuronal density more pronounced in the CA3 region of hippocampus. Neuronal density was reduced to 84.2 cells/ cu mm in experimental group as compared to 132.2 cells/ cu mm in control.

• Related Studies :

  • Fluoride activates microglia, secretes inflammatory factors and influences synaptic neuron plasticity in the hippocampus of rats.

    Epidemiological studies have reported that highly fluoridated drinking water may significantly decrease the Intelligence Quotient (IQ) of exposed children. It is thought that synaptic plasticity is the basis of learning and memory skills in developing children. However, the effect on synaptic plasticity by activated microglia induced via fluoride treatment is

  • Effects of fluoride on microtubule ultrastructure and expression of TubB1a and TubB2a in mouse hippocampus

    Axonal and dendrictic degenerations were observed in non-skeleton fluorosis as the neurological manifestations. Microtubules, composed of the assembled tubulin dimers, are the essential cytoskeleton of axon and dendron. However, the effect of fluoride (F) on microtubules status and tubulin dimer expression in central nerves system remains largely unknown. In this

  • Protective effect of lovastatin on neurotoxicity of excessive fluoride in primary hippocampal neurons

    The  protective  role  of  lovastatin  against  neurotoxicity  induced  by fluorosis was investigated by using primary hippocampal neurons. The cholesterol content,  activity  of  superoxide  dismutase   (SOD),  and  content  of  malondialdehyde (MDA)  were  measured  by  biochemical  assays.  The  cell  viability  was  assessed  by examining  the  rate  of  apoptosis  by  flow   cytometry.  The 

  • Effects of fluoride and lead on N-methyl-D-aspartate receptor 1 expression in the hippocampus of offspring rat pups

    To investigate whether excitotoxicity is involved in neurotoxicity of fluoride (F) alone and in combination with lead (Pb), the expression levels of the gene and protein N-methyl-D-aspartate receptor 1 (NMDAR1) in the hippocampus of offspring rat pups at postnatal days 14 and 28 exposed to F and/or Pb were determined by quantitative real-time polymerase

  • [Effects of fluoride on neural cell adhesion molecules mRNA and protein expression levels in primary rat hippocampal neurons].

    OBJECTIVE: To investigate the effects of fluoride on the growth and viability, and mRNA and protein expression levels of neural cell adhesion molecules (NCAM) in primary rat hippocampal neurons. METHODS: The growth and development, the rate of cell survivor, and the mRNA and protein expression levels of NCAM were measured by

• Related FAN Content :

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride & IQ: 68 Studies

    As of February 2021, a total of 76 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 68 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or