Abstract

The pilot study is conducted using 30 adult albino rats (200-250gm). They were divided into one control and one experimental group. Group 1 is Control (Ctrl), which received food and water ad-libitum, experimental group received, 20 ppm of sodium fluoride (NaF) for 7 weeks. The body weights and physical activity was significantly reduced in experimental group, whereas fluoride levels of hippocampus, was greatly increased. Light microscopy of the hippocampus, showed reduced neuronal density more pronounced in the CA3 region of hippocampus. Neuronal density was reduced to 84.2 cells/ cu mm in experimental group as compared to 132.2 cells/ cu mm in control.

• Related Studies :

  • Fluoride exposure during pregnancy and lactation triggers oxidative stress and molecular changes in hippocampus of offspring rats.

    Highlights Fluoride exposure indirectly increased the levels of F in the offspring's plasma. Fluorine exposure promoted biochemical imbalance in the offspring's hippocampus. The 10 mgF/L and 50 mgF/L groups showed an overexpression of the neurotrophin BDNF. In exposed groups modulation of the proteomic profile of the offspring. Proteins associated

  • [Study of the mechanism of neurone apoptosis in rats from the chronic fluorosis].

    Objective: Study the mechanism of action chronic fluorosis in neurones. Methods: Terminal deoxyribo-nucleotide transferase-mediated dUTP-biotin nick end labeling (TUNEL) and flow cytometry (FCM) were used to observe changes of apoptosis in cerebral cells in chronic fluorosis in rats. Results: TUNEL results show non-random expression of DAB positive stain apoptosis cells which appear

  • Effect of fluoride on calcium ion concentration and expression of nuclear transcription factor kappa-B p65 in rat hippocampus

    The study investigated the neurotoxicity of drinking water fluorosis in rat hippocampus. Just weaning male Sprague-Dawley (SD) rats were given 15, 30, 60 mg/L NaF solution and tap water for 9 months. The calcium ion concentration ([Ca(2+)]) in synaptosomes was measured by double wavelength fluorescence spectrophotometer and the expression level

  • Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice.

    SUMMARY: Learning-memory behavior was tested in mice on a Y-maze after they drank water containing different concentrations of sodium fluoride. Impairment of the structure of the Gray I synaptic interface in the CA3 area of the hippocampus was analyzed quantitatively by electron microscopy and a computer imaging processor. The main

  • Fluoride enhances the effect of aluminium chloride on interconnections between aggregates of hippocampal neurons

    The role of fluoride in aluminium neurotoxicity was studied using an in vitro system of cultured hippocampal neurons from foetal rats. Sodium fluoride (50 microM) and aluminium chloride (12.5 microM) were administered alone or in a specific combination (50 + 12.5 microM) in a 14-day culture in a chemically defined

• Related FAN Content :

  • Fluoride & IQ: 70 Studies

    As of June 2021, a total of 78 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 70 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching