Abstract

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    Young albino rabbits were administered 5, 10, 20, and 50 mg of sodium fluoride/kg body weight/day subcutaneously for 3.5 months. The control animals were given 1 mL of double distilled water/kg body weight/day. In the fluoridated rabbits, the myocardium showed cloudy swellings, sarcoplasmic vacuolization, and small hemorrhages followed by fibrous

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    Highlights F induced cardiomyocyte damage. F induced Ca2+ metabolic disorder. F inhibited the expression of cardiac troponin. F induced ultrastructure damage in cardiomyocytes. F interfered with production of ATP in cardiomyocytes. Our previous study indicated that excessive fluoride (F) induces ATP5J and ATP5H proactive expression by interfering cardiomyocyte mitochondrial dysfunction in

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    In the electrocardiogram of rabbits given sodium fluoride orally, a pattern of myocardial damage was observed, namely depressed ST, inverted T, prolonged QT interval, multifocal ventricular premature contraction, bundle branch block, and pulmonary P. Histologically, regressive degeneration, cellular infiltration, hyperemia, hemorrhages and thickening of vessel wall were noted in the

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    The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis

  • Fluoride & Myocardial Damage

    Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha

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    Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et

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    Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the

  • Fluoride & Electrocardiogram Abnormalities

    An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems