BACKGROUND: Recent studies have reported an inverse association between fluoride exposure and IQ in children, but most were ecological in design. Few involved personal measures of exposure or adjusted for confounders.
METHODS: This study utilized archived urine samples and data from offspring who participated in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) pregnancy and birth cohort project to study concurrent fluoride exposure and its association with cognitive outcomes in 565 children ages 7-15 years old. Generalized Additive Models (GAM) were used to test the association between specific gravity-adjusted urinary fluoride levels and total score from the Wechsler Abbreviated Scale of Intelligence (WASI), adjusting for child’s sex, child’s age, gestational age, birth weight, birth order, maternal intelligence score, maternal age, maternal education, marital status, maternal education, maternal smoking history, family possessions, and cohort. GAM were also re-run after stratifying by sex (NMales = 298, NFemales = 267).
RESULTS: Concurrent urinary fluoride was not significantly associated with WASI scores in children, and sex did not modify the association.
CONCLUSIONS: The results of this cross-sectional study do not support the hypothesis that concurrent fluoride exposure has an impact on cognitive function among children aged 7-15 years.
*Abstract in the Conference Abstract E-Book at http://fluoridealert.org/wp-content/uploads/isee2020.abstract-e-book..pdf
This abstract was presented in ORAL SESSION 14 at the virtual 32nd Conference of ISEE.
B. Thomas, Cornell University Ithaca NY
Lin, Brown University Providence RI
Peterson, University, University of Michigan, Ann Arbor, MI
N. Sanchez, Drexel University, Philadelphia, PA,
Basu, McGill University, Montreal, QC, CANADA
Martinez-Mier, Indiana University, Indianapolis, IN
Mercado-Garcia, Instituto Nacional de Slaud Publica, Cuernavaca, MEXICO
Schnaas, Instituto Nacional de Slaud Publica, Cuernavaca, MEXICO
Till, York University, Toronto, ON, CANADA
Hernandez-Avila, Instituto Nacional de Slaud Publica, Cuernavaca, MEXICO
Hu, University of Washington, Seattle, WA
Tellez-Rojo, Instituto Nacional de Slaud Publica, Cuernavaca, MEXICO
Related Studies :
Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico
Background: Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures of fluoride exposure, addressed the impact of prenatal exposures or involved more than 100 participants.
OBJECTIVE: Our aim was to estimate the association of prenatal exposure to fluoride with
The importance of timing in fluoride-induced developmental neurotoxicity.
Exposure to the fluoride ion can, in sufficient dose, induce neurotoxicity at any age, in both adults and children, but for fluoride-induced neurotoxicity to occur, in response to exposure to low doses of fluoride in the developing brain, the timing of the exposure is of importance. The evidence to date
WITHDRAWN: Co-exposure effects of arsenic and fluoride on intelligence and oxidative stress in school-aged children: a cohort study.
This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause.
as of November 6, 2020
Pioneer biomonitoring study on rural children to address As and F- co-exposure.
High dental Fluorosis found in relation to urinary As and F- levels in
Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) Project.
PURPOSE: The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother-child pregnancy and birth cohort originally initiated in the mid-1990s to explore: (1) whether enhanced mobilisation of lead from maternal bone stores during pregnancy poses a risk to fetal and subsequent offspring neurodevelopment; and (2) whether
Impacts of Fluoride Neurotoxicity and Mitochondrial Dysfunction on Cognition and Mental Health: A Literature Review.
This review focuses on the synthesis of current experimental and observational data regarding the effect of fluoride exposure on childhood mental health and the role of mitochondrial function as a mechanism of action. We aggregated data on the relationships between fluoride neurotoxicity, mitochondrial function, and cognitive and mental health using
Related FAN Content :
Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning.
As highlighted by the excerpts
Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
Fluoride: Developmental Neurotoxicity.
There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder.
Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.
Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients
Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,