- Fluoride can protect enamel from demineralisation and promote remineralization.
- A sodium fluoride/potassium nitrate/cocamidopropyl betaine dentifrice was examined.
- Compared to a NaF/KNO3/sodium lauryl sulphate/tetrasodium pyrophosphate dentifrice.
- Greater salivary fluoride/calcium ion concentration found with the test dentifrice.
- Formulation excipients may impact fluoride and calcium ion oral cavity retention.
OBJECTIVE: This exploratory, randomised, single-blind, crossover, study evaluated fluoride and calcium ion concentrations and pH following use of one of two 1450 ppm fluoride (NaF), 5% w/w KNO3 dentifrices: (1) test dentifrice (with cocamidopropyl betaine) with an orange juice (OJ) rinse; (2) test dentifrice with a deionized (DI) water rinse or (3) comparator dentifrice (with sodium lauryl sulphate and tetrasodium pyrophosphate) with an OJ rinse.
DESIGN: Eighteen participants used their assigned dentifrice, rinsed with DI water, then expectorate was collected. Sixty min post-brushing, participants rinsed with OJ or DI water then expectorate was collected. Saliva samples were collected pre-brushing and at 1, 5, 10, 15, 30 and 60 min post-brushing and following the 60 min OJ/DI water rinse. The pH of samples was taken.
RESULTS: Significant differences (p < 0.05) were found in salivary fluoride ion concentrations between test and comparator dentifrices at 30 and 60 min and following the 60 min OJ rinse, favouring the former. Significant differences were also found between test and comparator dentifrices for salivary calcium ion concentration at 1, 5 and 10 min (p < 0.0001), favouring the former, and between test or comparator + OJ rinse and test + water rinse (p < 0.005), favouring the latter. No pH differences were shown prior to OJ/water rinse. Products were generally well-tolerated.
CONCLUSIONS: Results confirmed that acid-labile fluoride is released from the oral cavity following a dietary acid challenge and showed that formulation excipients may impact on retention of such.
Editorial assistance with the preparation of manuscript drafts was provided by Juliette Allport, Leading Edge, and Eleanor Roberts, Beeline Science Communications Ltd., both funded by GSK Consumer Healthcare [GlaxoSmithKline]
*Read full text online at https://www.sciencedirect.com/science/article/pii/S0003996920302697#!
[Fluoride levels in saliva after tooth-brushing using fluoride toothpastes with and without rinsing of oral cavity].
PURPOSE: The aim of the study was to determine salivary fluoride concentrations after tooth-brushing with fluoride toothpastes with and without rinsing of oral cavity. MATERIAL AND METHODS: Fluoride levels in the supernatant of unstimulated mixed saliva were measured after tooth-brushing with Elmex (amine fluoride, 0.125% F) and Meridol (amine fluoride, stannous(II)
Fluoride Levels in Saliva and Plaque following the Use of High Fluoride and Conventional Dentifrices- a Triple Blinded Randomised Parallel Group Trial.
Context: The comparison of fluoride levels in saliva and plaque following the use of conventional, 2800 and 5000 ppm dentifrices for different time intervals up to 24 hours has not been explored. Aim: The aim of the present study was to assess salivary and plaque fluoride levels at different time intervals
Randomised study of intra-oral kinetics of fluoride-containing toothpastes.
Objectives: This randomised, controlled, analyst blind, crossover study aimed to evaluate and compare salivary fluoride and calcium ion concentration over 60 min following brushing with an assigned treatment and following an orange juice (OJ) or deionised (DI) water rinse 60 min post-brushing. Methods: Study treatments, both containing
Predictors of Plasma Fluoride Concentrations in Children and Adolescents.
Despite increasing concerns about neurotoxicity of fluoride in children, sources of fluoride exposure apart from municipal water fluoridation are poorly understood. We aimed to describe the associations of demographics, drinking water characteristics, diet, and oral health behaviors with plasma fluoride concentrations in U.S. children. We used data from 3928 6–19-year-olds
Gastrointestinal Absorption and Renal Excretion of Fluoride After Ingestion of a High-Fluoride Dentifrice.
This study aimed to evaluate the gastrointestinal absorption and renal excretion of fluoride after the ingestion of high-fluoride dentifrice. Twelve volunteers participated in this in vivo, crossover, and blinded study. In three experimental phases, the volunteers were randomly assigned to one of three treatment groups, who ingested either the following:
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