- Immediate decontamination proved to be crucial to limit fluoride absorption.
- All decontamination strategies and water alone reduced dermal fluoride absorption.
- Buffer capacity may account for efficiency differences between decontaminants.
The fluoride ions of the industrially largely irreplaceable, locally corrosive hydrofluoric acid (HF) can scavenge cations in biological tissues, which explains their high toxic potential, and also leads to local acidification through proton release. The influence of three complexing agents, calcium (Ca2+) gluconate (as 2.5% Ca2+gel and individually (2.84%) or commercially (10%) formulated Ca2+solution), magnesium (Mg2+) gluconate (2.84%) solution and aluminium (Al3+) solution (Hexafluorine®, pure and diluted) on the absorption of fluoride following HF exposure (1–3 min, 100 ul, 30%/0.64 cm2) through human skin was investigated in an ex-vivo diffusion cell model. Fluoride absorption was assessed over 6–24 h and analysed with a fluoride electrode. Decreasing the contamination time reduced the fluoride absorption distinctly which was further reduced by the application of fluoride-binding decontamination agents (Ca2+, Mg2+, Al3+) or water alone without being significantly different. Ca2+ appeared slightly more effective than Mg2+ in reducing fluoride absorption. Moreover, the addition of pH adjusting buffer promoted the decontamination efficacy. Fluoride-binding agents can facilitate the decontamination of dermal HF exposure. However, prompt decontamination appeared to be the key to successful limitation of fluoride absorption and pushes the choice of decontamination agent almost into the background.
*Original abstract online at https://www.sciencedirect.com/science/article/abs/pii/S088723332030607X
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SUMMARY Data is presented showing that fluoride ingested by gravid women enters the maternal circulation, is stored in the placenta and passes through the placental barrier to enter the foetal blood supply. Evidence is presented that the fluoride in the foetal blood supply affects the developing teeth to make them more resistant
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Application of ammonium fluoride under an occlusive patch to the abdomen of a rabbit converts a simple scratch into a double row of sterile pustules. Sodium fluoride produces a similar response, but ammonium chloride does not produce pustules. . . . It appears that tissue damage and the presence of fluorides
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Contamination of arsenic and fluoride in drinking water reservoirs is a serious health issue in the Sibi district, Balochistan, Pakistan. The contamination has already been affecting a large population of the district. Dental fluorosis and dermatitis are the most common reported illnesses in the area. This study focused on the
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