Forty male students were each exposed on two occasions to four hours of inhalation of either air or 500 ppm nitrous oxide with or without 15 ppm halothane in air. Immediately following exposure, a battery of tests of perceptual, cognitive and motor skills was administered. Compared with responses after breathing of air, those after exposure to nitrous oxide and halothane showed significant decrements in performances of a task in which attention was divided between auditory and visual signals, a visual tachistoscopic test, and memory tests involving digit span and recall of word pairs. Subjects exposed to nitrous oxide alone scored
significantly lower on the digit-span test only.
(Key words: Anesthetics, Volatile: halothane; Anesthetics, gases: nitrous oxide; Psychologic function.)
1. Linde HV, Bruce DL: Occupational exposure of anesthetists to halothane. nitrous oxide and radiation. Anesthesiology 30:363-368, 1969.
2. Corbett TH: Retention of anesthetic agents following occupational exposure. Anestl, Analg (Cleve) 52:614-Gli, 1973.
3. Salvini M, Binaschi S, Riva M: Evaluation of the psychophysiological functions in humans exposed to trichloroethylene. Br J Ind Med 28:293-295, 1971.
4. Bruce DL: A simple way to vent anesthetic gases. Anesth Analg (Cleve) 52:595-598, 197.3
Letter to the Editor: IQ of 9-12 year-old children in high and low-drinking water fluoride areas in West Axerbaijan Province, Iran: Further information on the two villages in the study and the confounding factors considered.
In a critique of our study1 on the IQ of 9–12-year-old children in high- and low drinking water fluoride (F) areas in West Azerbaijan province, Iran, Dr Ken Perrott questioned whether possible confounding factors in the two villages, such as the rural status and parental educational levels, were adequately considered.2 Perrott’s
The impact of endemic fluorosis caused by the burning of coal on the development of intelligence in children.
Objective: To explore the effect of endemic fluorosis caused by coal burning on the level of intelligence in children. The Method: We randomly selected 20 school children from 4 areas between the ages of 812, whose characteristics fit the scope of our research. They were chosen from slight, moderate, and severe endemic
Evaluation of Metformin and Dehydrozingerone against fluorosis induced neurodevelopmental toxicity in preclinical models.
Background: Inorganic fluoride is widely used in dental practices to treat problems like dental caries and also to prevent bone related issues. It has been reported that exposure to excess amounts of fluoride either through drinking water or other sources impairs vital functions of the body and can
Effects of fluoride and lead on locomotor behavior and expression of nissl body in brain of adult rats.
By means of an activity chamber and a Y-maze, spontaneous and conditioned-response behaviors, respectively, of adult Wistar albino rats were determined after administration of sodium fluoride (150 mg/L) and/or lead acetate (300 mg/L) in their drinking water for 30 days. The dental status and the expression of Nissl body in
Fluoride and its effect on human intelligence: a systematic review.
Objectives: A systematic review was undertaken to examine if fluoride (F-) exposure is associated with a decline in human intelligence (IQ). Materials and Methods: Ovid MEDLINE and its allied versions, CINAHL, AMED, EMBASE, Cochrane DSR, ACP Journal Club, DARE, CCTR, CMR, HTA, and NHSEED, Health and Psychosocial Instruments, HealthSTAR, International
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
Fluoride & IQ: 76 Studies
Note: See the Updated list of fluoride IQ studies at https://fluoridealert.org/researchers/fluoride-iq-studies/the-fluoride-iq-studies/ • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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