Excerpt:
… Agrochemicals are generally considered as the causal factors for many of the non-communicable diseases (NCDs), especially the chronic kidney disease of uncertain etiology (CKDu). Such unproven ideology has been forced into minds of people who are suffering from the disease. Some even dubbed CKDu as ‘Agricultural kidney disease’. This propaganda campaign has brainwashed not only the unfortunate patients, but also the general public and policy makers and thus, creating fear against an important agricultural input.
… The “demon” created in people’s mind with respect to use of fertilizer and its impact on NCDs such as CKDu was comprehensively refuted recently by the Chairman of the National Research Council (NRC) of Sri Lanka, appearing in a popular TV discussion. The Chairman/NRC clearly stated that the most recent research completed under the funding from NRC has concluded that not drinking adequate volumes of water and the high fluoride content in ground water as the two major causal factors for the CKDu in Anuradhapura area. He further stated that the disease is not due to heavy metals and that this information has been provided to the Ministry of Health…
*Original article online at https://island.lk/a-tragedy-of-relying-on-misinformation/
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Effect of sodium fluoride on the expression of Bcl-2 family and osteopontin in rat renal tubular cells
Our earlier studies showed that the apoptosis of renal tubules can be induced by sodium fluoride (NaF). The present study was designed to estimated the effects of B-cell lymphoma/leukemia 2 (Bcl-2), Bcl-2-associated protein X (Bax), and osteopontin (OPN) on the apoptosis of renal tubular cells induced by NaF at different
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Histopathological changes of renal tissue following sodium fluoride administration in two consecutive generations of mice. Correlation with the urinary elimination of fluoride
The present study was designed to investigate the toxic effects (evaluated as histopathological changes) of sodium fluoride on the kidney in two consecutive generations of NMRI mice. An attempt to correlate the toxicity with the urinary elimination of fluoride has been made, as urinary fluoride excretion has been widely used
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A case of distal renal tubular acidosis, Southeast Asian ovalocytosis and possible fluorosis
A 39-year old man had periodic paralysis due to hypokalaemia. Investigations led to the diagnosis of distal renal tubular acidosis (dRTA) and Southeast Asian ovalocytosis (SAO). Both can originate in mutations of the anion-exchanger 1 gene (AE1), which codes for band 3, the bicarbonate/chloride exchanger in both the red cell
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Epigallocatechin gallate supplementation protects against renal injury induced by fluoride intoxication in rats: Role of Nrf2/HO-1 signaling
Fluoride intoxication generates free radicals, causing oxidative stress that plays a critical role in the progression of nephropathy. In the present study, we hypothesized that epigallocatechin gallate (EGCG), found in green tea, protects the kidneys of rats treated with fluoride by preventing oxidative stress, inflammation, and apoptosis. Pretreatment of fluoride-treated
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Fluoridation of drinking water and chronic kidney disease: absence of evidence is not evidence of absence.
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