Abstract

Fluoride concentrations were measured in mandibles of 112 male roe deer (Capreolus capreolus) aged 1–6 years, from 5 localities in England and Scotland; also in bone from sections cut in series from orbit to antler-top of 10 other roe deer. Fluoride concentrations in mandibles were mostly within values expected from unpolluted areas, but approached those expected from moderately polluted areas at the upper end of their range, which extended from 43 to 901 ug g-¹. There were large variations in mandibular fluoride content between individual animals within each age group, and an upward trend of fluoride content with increasing age. There were also considerable differences in mandibular fluoride content between localities. No gradient in fluoride concentration was evident between the upper part of the skull and various points along the antler in 9 roe deer. A tenth animal showed an increase of 65% in fluoride concentration between the skull and the top of the antler, with exceptionally high values ranging from 1220 to 2010 u g^-1. For 3 red deer (Cervus elaphus), no significant differences in fluoride concentrations were found between trabecular and cortical antler bone.

*Original abstract online at https://www.sciencedirect.com/science/article/abs/pii/0269749188901728

• Related Studies :

  • Studies on skeletal muscle biopsies in endemic skeletal fluorosis

    Neurological manifestations of skeletal fluorosis have been attributed to compressive radiculomyelopathy. Experimental fluorosis has shown evidence of myopathic changes. Data on human muscle pathology is very scanty. This study included 22 patients with established osteofluorosis. 16 of them showed only EMG changes of neurogenic muscle disease. Histochemistry and histopathology of muscle biopsies showed

  • [Threshold effects of body mass index on the bone mineral density of Chinese rural women in fluorosis area]

    To explore the threshold effect of body mass index (BMI) on bone mineral density (BMD) in Chinese women living in the fluorosis area, we conducted a cross-sectional study and recruited 722 women in rural areas in Henan Province, China. After detection and analyses, we found that compared with the normal

  • Hip fracture incidence before and after the fluoridation of the public water supply, Rochester, Minnesota

    Recent ecological comparison studies have suggested a positive association between fluoridation and hip fracture. Using data from the Rochester Epidemiology Project, we found the incidence of hip fracture for the 10 years before the fluoridation of the Rochester, Minn, public water supply was 484 per 100,000, compared with 450 per

  • Effects of sodium fluoride, vitamin D, and calcium on cortical bone remodeling in osteoporotic patients

    The purpose of this histomorphometric study of iliac bone biopsies from 10 postmenopausal osteoporotic patients was to describe the effects of sodium fluoride (combined with calcium and vitamin D) on remodeling in cortical bone after 6 months and after 5 years of treatment. Biopsies had been fixed in absolute methanol,

  • Elevated serum fluoride concentrations in women are not related to fractures and bone mineral density.

    Epidemiologic studies of the relations between drinking-water fluoride levels and bone mineral density (BMD) and fracture are characterized by disparate conclusions and an absence of information about individual circulating fluoride levels. This study relates serum fluoride concentrations, which reflect individual fluoride exposures, to BMD and bone fractures. Data are from

• Related FAN Content :

  • Fluoride & Osteoarthritis

    While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.

  • Skeletal Fluorosis: The Misdiagnosis Problem

    It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.

  • "Pre-Skeletal" Fluorosis

    As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.