- Impact of F, Cd & Pb on human health is related to the various routes of exposure.
- Cd, Pb & F levels in human blood was higher around the phosphate plant in Togo.
- Cd, Pb &F content in human blood declined while moving away from phosphate plant.
- Biochemical parameters revealed renal & liver disease risk to people near factory.
- High F along with biochemical parameters signals risk of renal & hepatic diseases.
Togo’s phosphate processing plant at Kpeme discharges waste, containing Cd, Pb, and fluoride, into the sea and on the soil. Heavy metals toxicity on kidneys and the liver has been studied. However, fluoride toxicity on these organs remains to be investigated. The present study deals with the variation in renal and hepatic functioning parameters due to fluoride, Cd and Pb. Totally, 350 volunteers were recruited from five different localities around this phosphate processing plant for sample collection. Cd and Pb contents in blood samples were determined by spectrophotometry and fluoride by the titanium chloride method. Biochemical parameters were measured using Biolab kits. The pollutant contents were elevated in polluted areas where ASAT, ALAT, creatinine, and urea increased, and total protein decreased. Correlation and multivariate tests showed that fluoride is related to the various pathologies mentioned. PCA revealed that phosphate processing in Togo is a source of renal and hepatic toxicity.
*Full-text study online at https://www.sciencedirect.com/science/article/pii/S0946672X21001802?via%3Dihub
Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016.
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Author Correction: Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway.
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The Influence of fluoride on chronic kidney disease of uncertain aetiology (CKDu) in Sri Lanka.
Fluoride is an element that is widely distributed in the environment. The involvement of fluoride in pathogenesis of Chronic Kidney Disease of uncertain aetiology (CKDu) in Sri Lanka is a much-debated topic. This study aimed to investigate the fluoride concentration in drinking water in CKDu affected areas in Sri Lanka
Assessment of renal and hepatic dysfunction by co-exposure to toxic metals (Cd, Pb) and fluoride in people living nearby an industrial zone.
Highlights Impact of F, Cd & Pb on human health is related to the various routes of exposure. Cd, Pb & F levels in human blood was higher around the phosphate plant in Togo. Cd, Pb &F content in human blood declined while moving away from phosphate plant. Biochemical
Effect of fluoride on major organs with the different time of exposure in rats.
BACKGROUND: High fluoride levels in drinking water in relation to the prevalence of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka were investigated using rats as an experimental model. METHOD: The effects of fluoride after oral administration of Sodium fluoride (NaF) at levels of 0, 0.5, 5 and 20 ppm F- were evaluated
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