The distribution of fluoride of prenatal origin in the rat–a pilot study.

References (31) P.F. DePaola et al. A pilot study of the relationship between caries experience and surface enamel fluoride in man Archs oral Biol. (1975) R.G. Schamschula et al. Associations between fluoride concentration in successive layers of human enamel and individual dental caries experience Archs oral Biol. (1979) D.R. Taves Determination of submicromolar concentrations of fluoride in biological samples Talanta (1968) G.M. Whitford et al. Plasma an

Abstract

Sixteen female, Sprague-Dawley rats were divided into four equal groups. Two groups served as controls receiving low or regular concentrations of fluoride (F); animals in the other two groups were given drinking water, containing 100 parts/10(6) F, for 3 weeks either during or immediately before pregnancy. Thirteen days after delivery, the pups and dams were killed and various tissues analysed for F content. Prenatal F supplementation increased F concentrations in plasma, mandibular incisors and femoral epiphyses of pups by 25, 36 and 38% respectively, when given during pregnancy. Only a slight increase of 9 and 11% in the respective F concentrations of incisors and epiphyses occurred when the supplement was given before pregnancy. The fluoride level of milk was consistently higher than that of the maternal plasma. These results suggest the need for further study of prenatal F supplementation.

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*Abstract online at https://europepmc.org/article/MED/2610622

References (31)

• P.F. DePaola et al.
  

  A pilot study of the relationship between caries experience and surface enamel fluoride in man

  Archs oral Biol.

  (1975)
• R.G. Schamschula et al.
  

  Associations between fluoride concentration in successive layers of human enamel and individual dental caries experience

  Archs oral Biol.

  (1979)
• D.R. Taves
  

  Determination of submicromolar concentrations of fluoride in biological samples

  Talanta

  (1968)
• G.M. Whitford et al.
  

  Plasma and developing enamel fluoride concentration during chronic acid-base disturbances

  J. dent. Res.

  (1979)
• J.A. Weatherell et al.
  

  Assimulation of fluoride by enamel throughout the life of the tooth

  Caries Res.

  (1977)
• A. Thylstrup
  

  Is there a biological rationale for prenatal fluoride administration?

  J. dent. Child.

  (1981)
• J.W. Stamm
  

  Perspectives on the use of prenatal fluorides: a reactors comment

  J. dent. Child.

  (1981)
• J.D. Speake et al.
  

  The prevalence of dental caries and the concentration of fluoride in the enamel of children in the South Pacific

  N.Z. dent. J.

  (1979)
• L.M. Silverstone
• L.M. Silverstone
• J.H. Shaw
• L.W. Ripa
  

  Topical fluorides: a discussion of risks and benefits

  J. dent. Res.

  (1987)
• J.D. Perkinson et al.
  

  Metabolism of fluorine 18 in domestic animals

  Am. J. Physiol.

  (1955)
• P.R. Parker et al.
  

  Prenatal fluoride exposure: measurement of plasma levels and enamel uptake in the guinea pig

  J. dent. Res.

  (1986)
• E. Newbrun