- Fluoride impairs the intestinal epithelial cells of the host.
- The intestinal microbiota structure of the host organism is altered by fluoride.
- Amino acid and nucleotide metabolisms are perturbed by extreme fluoride intake.
- Supplementary probiotics is a potential preventive therapy for host fluorosis.
- Fluoride disrupts the microbiota-gut-blood barrier functions of host organisms.
Fluoride is a serious health risk to animals and humans. The microbiota-gut-blood barrier (MGBB) plays an indispensable role in maintaining the systematic homeostasis of host organisms. However, the toxic effects of fluoride on MGBB of organisms have not been extensively investigated. Here, we used the silkworm interspecies model to explore the adverse effects of fluoride on the gut microbiota and intestinal tissue and circulating metabolites of organisms. Results showed that fluoride exposure significantly declined the body weight gain and survival rate of organisms and evidently damaged intestinal epithelial cells. In addition, fluoride altered the composition and abundance of intestinal microbiota, which was accompanied by changing gene expression levels of antimicrobial peptides in intestinal tissue. Shifts in the relative abundance of Enterococcus, Aquabacterium, Aureimonas and Methylobacterium in the gut had significant correlations with the concentrations of certain differential metabolites (e.g., amino acids, nucleotides, and nucleotide derivatives) in the bloodstream. Moreover, most circulating metabolites in related nucleotide metabolism pathways were upregulated, whereas those in the pathways of amino acid metabolism were downregulated. This study deepens our understanding of the disruptive effect of fluoride on the MGBB of host organisms and may provide a new insight into the preventive therapy of fluoride-induced diseases.
*Original abstract online at https://www.sciencedirect.com/science/article/abs/pii/S0048969722033174?via%3Dihub
Outbreak of acute fluoride poisoning caused by a fluoride overfeed, Mississippi, 1993.
OBJECTIVE: To determine the extent and confirm the cause of an August 1993 outbreak of acute fluoride poisoning in a small Mississippi community, thought to result from excess fluoride in the public water supply. METHODS: State health department investigators interviewed patrons of a restaurant where the outbreak first became manifest and
Prenatal and postnatal ingestion of fluorides: fourteen years of investigation -- final report*.
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Mass intoxication from accidental overfluoridation of drinking water.
The literature reveals several episodes of acute mass poisoning due to sodium fluoride which had been mistaken for flour, sugar, and baking powder and added to food . The number of persons affected ranged from 5 to 280. The most severe accident -with 47 deaths occurred in Salem, Oregon, where
Fluoride toxicosis in immature herbivorous domestic animals living in low fluoride water endemic areas of Rajasthan, India: An observational survey
Susceptibility to fluoride toxicosis in the form of osteo-dental fluorosis was observed among 435 immature herbivorous domestic animals living in areas with less than 1.5 ppm fluoride in the drinking water. These animals included 78 buffaloes (Bubalus bubalis), 89 cattle (Bos taurus), 30 donkeys (Equus asinus), 21 horses (Equus caballus),
Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D.
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